Motoko Yanagita (Kyoto University)
Eiji Hara (The University of Osaka)
Akiyoshi Uezumi (Kyushu University)
Masaki Takasugi (Osaka Metropolitan University)
Kei Igarashi (University of California)

This symposium will focus on age-related changes across various organs, examining both the tissue microenvironment and inter-organ networks at cellular and molecular levels. Additionally, it will address the significance of cellular senescence in aged organs and present the findings from proteomic analyses of systemic protein changes associated with aging. Under the session title "Unraveling Aging with Molecular and Cellular Biochemistry," we will feature cutting-edge research presentations in this field. This symposium is co-hosted by JST PRESTO's “Aging" program.

Sidonia Fagarasan (RIKEN)
Kenji Chamoto (Kyoto University)
Yosuke Togashi (Okayama University)
Yusuke Endo (Kazusa DNA Research Institute)
Di Yu (The University of Queensland)

The mechanisms by which metabolic pathways and metabolites influence immune cell function remain largely unexplored. In this symposium, five researchers will present their latest findings on these topics. The discussion will focus on the roles of mitochondria, fatty acid metabolism, metabolites oxidative stress in immune responses and tumor immunity. Energy metabolism, composed of interconnected pathways, maintains homeostasis, and its disruption can lead to various diseases. By regulating energy metabolism, there is potential to treat immune disorders, including tumor immunity. Here we will explore new therapeutic approaches based on these emerging insights.

Goro Yoshizaki (Tokyo University of Marine Science and Technology)
Mariko Kikuchi (Nagoya University)
Kaori Sano (Josai University)
Seiji Wada (Aoyama Gakuin University)
Ayaka Fukuda (National Institute for Basic Biology)
Tohru Ishitani (The University of Osaka)

Fish models like zebrafish and medaka offer in vivo imaging and sample acquisition advantages. Their species diversity and advancements in genome editing and omics technologies have opened "new horizons in life sciences," challenging future discoveries. This symposium highlights research in reproductive biology, evolutionary science, neuroendocrinology, neurobehavioral studies, and aging, using strengths of fish species with biochemical approaches. We aim to showcase fish biochemistry research linked to diverse fields like life sciences, medicine, fisheries, and ecology.

Koshi Imami (RIKEN)
Akiko Oguchi (RIKEN)
Seitaro Nomura (The University of Tokyo)
Shintaro Iwasaki (RIKEN)
Mikhail Savitsky (European Molecular Biology Laboratory)

Advancements in next-generation sequencing and mass spectrometry have revealed increasingly complex mechanisms regulating gene and protein expression, surpassing the traditional boundaries of the central dogma. These innovations have highlighted previously overlooked gene regulatory processes and molecular interactions. New insights into transcriptional and post-transcriptional regulation, and the roles of non-coding RNAs, are gaining attention in biology. The evolution of these cutting-edge omics technologies is driving transformative changes in basic and disease research, including drug discovery. This symposium will discuss these breakthroughs and the latest biological findings.

Ivan Dikic (Goethe University Frankfurt )
Noboru Mizushima (The University of Tokyo)
Nobuo Noda (Hokkaido University)
Hitoshi Nakatogawa (Institute of Science Tokyo)
Masaaki Komatsu (Juntendo University)

Autophagy is an intracellular system that delivers a wide range of cellular components to lysosomes or vacuoles for degradation, playing critical roles in maintaining and regulating various biological functions. Its aberration has been linked to different human diseases. The molecular mechanisms and physiological functions of autophagy have so far been revealed through extensive research. However, the field, while integrating new technologies and emerging trends in life sciences, continues to deepen and also expands into new frontiers, such as selective organelle degradation and the dynamic interplay between protein condensates and lipid membranes. This symposium will gather leading researchers who have advanced the field of autophagy to share the latest findings and discuss future challenges and directions.

Motohiko Kadoki (Harvard Medical School)
Yoji Andrew Minamishima (Gunma University)
Yasuhiro Saito (Keio University)
Kazuyoshi Ishigaki (Keio University)
Akinobu Matsumoto (Nagoya University)

The recent decline of the Japanese presence in science is one of the concerns in our scientific community. The United States remains a strong leader, and Boston, MA, is one of the top biomedical research hubs consisting of major universities (Harvard and MIT), research institutes (Mass General Hospital, Broad Institute, etc…), big and startup biotech companies (Pfizer, Takeda, Novartis, Moderna, etc…), and venture capitals. In this session, through the presentations of researchers of wide fields in life science who study both in Boston and Japan, we will obtain clues to the resilience of Japanese science. Each speaker will talk about not only their science but also the differences between Japan and the US/Boston in the research environment and the mindset for continuing innovation.

Mikihiko Naito (The University of Tokyo)
Alessio Ciulli (Dundee University)
Satoshi Yamanaka (Ehime University)
Tim Clausen (Research Institute of Molecular Pathology)
Minoru Ishikawa (Tohoku University)

Thanks to the establishment of PROTAC technology, which specifically degrades target proteins, novel drug development based on this technology is being actively conducted around the world. The original PROTAC degrades target proteins in animal cells, and more than twenty PROTACs are under clinical development against various cancers. Recently BacPROTAC, which acts on bacteria, has been developed and is attracting attention as a novel technology for developing new antibacterial agents.In this symposium, we have invited five speakers who are leading PROTAC research in the world to introduce the frontiers of PROTAC research, including the development of PROTACs for drug discovery, the application of PROTAC technology to basic research, and the development of BacPROTAC and MitTPD.

Fumiki Katsuoka (Tohoku University)
Takafumi Suzuki (Tohoku University)
Yukari Yasui (Chugai Pharmaceutical Co., Ltd.)
Yukiko Yoshida (Tokyo Metropolitan Institute of Medical Science)
Nobunao Wakabayashi (Fred Hutchinson Cancer Center)
Tsuyoshi Waku (Doshisha University)

CNC factors and small MAF factors (sMAFs), which are bZIP-type transcription factors, recognize a common DNA cis-element by forming dimers and regulate gene expression.Among CNC factors, the contribution of NRF2 to the oxidative stress response was the first studied, but the contribution of NRF1 and NRF3 to proteostasis has been revealed, and the study of novel physiological functions of CNC factors continues to this day. Dysregulation of CNC-sMAF dimers has been linked to an increased risk of disease and cancer progression.Given CNC factors' shared DNA cis-element, it is crucial to understand their interactions.This symposium will present the latest findings, provide a overview of the system, and explore new avenues for both basic science and drug discovery.

Kyosuke Yanagawa (Harvard Medical School)
Eiji Morita (Hirosaki Univerisity)
Tomoyoshi Yamano (Kanazawa University)
Keisuke Goda (The Univeristy of Tokyo)
Shiro Suetsugu (Nara Institute of Science and Technology)
Mitsunori Fukuda (Tohoku University)
Ken Sato (Gunma University)

Cells in multicellular organisms recognize each other through the exchange of materials. This exchange occurs through the secretion of small molecules and the membrane structures for delivering non-secreting materials and organelles. The membrane structures for exchanging materials are generated by the membrane fusion and deformation and are recognized by the target through the receptor-ligand interaction. The engineering of these exchanges helps to understand the physiology and pathology of the organisms, including development and senescence. This symposium will focus on membrane remodeling in these events for their commonalities and differences.

Kentaro Tomii (AIST)
George Chikenji (Nagoya University)
Kei-ichi Okazaki (Institute for Molecular Science)
Naoya Kobayashi (Nara Institute of Science and Technology)
Masahito Ohue (Institute of Science Tokyo)
Yoshitaka Moriwaki (Institute of Science Tokyo)

Five years since the advent of AlphaFold, its use has rapidly spread, and today, structure prediction and structure searches are performed as casually as BLAST sequence homology searches. This has become a routine practice to infer protein functions and interactions. From the perspective of computational research, many new AI technologies have been developed, inspired by the ideas behind AlphaFold. In this symposium, we aim to organize the current state of AlphaFold from the standpoint of computational researchers and discuss what has been made possible by AlphaFold and its surrounding technologies, as well as what challenges remain to be solved in the future.

Tomokazu Ito (Nagoya University)
Takeshi Imai (Hyogo Prefectural Institute of Technology)
Tomomi Sumida (JAMSTEC)
Yoko Chiba (RIKEN)
Shogo Nakano (University of Shizuoka)

Enzyme and metabolism research is the foundation of biochemistry and remains essential for diverse biochemical studies. Recently, new trends have emerged in this field, supported by vast genome data, evolving omics technologies, and innovative AI. This symposium will feature young researchers presenting their latest findings on topics such as coenzyme dynamics, proteostasis control, enzyme discovery using metagenomics, biosynthetic pathway diversity, and the design of high-performance enzymes. The symposium will provide an opportunity to recognize new trends in this field and consider future directions.

Naoko Oda-Ueda (Sojo University)
Hiroki Shibata (Kyushu University)
Akira Mori (Kyoto University)
Masakazu Tokita (Toho University)
Takayuki Suzuki (Osaka Metropolitan University)
Yuji Atsuta (Kyushu University)
Tomohisa Ogawa (Tohoku University)

This Year Marks the Year of the Snake! Snakes are fascinating creatures that possess a dual nature: while their slithering bodies often evoke fear and aversion, their ability to shed their skin repeatedly has made them symbols of "rebirth and growth," revered in myths, legends, and spiritual beliefs throughout history. This symposium will focus on the mysteries of snakes and provide a forum to look at snakes from a variety of perspectives, including the mechanisms of venom secretion and recycling, the mechanisms of snake development and skeletal formation, the evolution of venom components as revealed by the decoding of the genome of the venomous Habu snake, and its application in medicine. Furthermore, we hope to uncover valuable insights from the distinctive molecular mechanisms that snakes have evolved, potentially contributing to advancements that benefit human life.

Shinpei Yamaguchi (Toho University)
Akihisa Osakabe (The University of Tokyo)
Kyohei Arita (Yokohama City University)
Kousuke Yamaguchi (National Institute of Genetics)
Taiko KIM To (Institute of Science Tokyo)
Atsuya Nishiyama (The University of Tokyo)

DNA methylation is a fundamental process in epigenetic regulation, playing crucial roles in transposon silencing, development, differentiation, environmental responses, and disease regulation. However, many aspects of its regulatory mechanisms remain unresolved. This symposium will explore novel mechanisms of DNA methylation regulation through a multidisciplinary approach that integrates cutting-edge research in structural biology, cell biology, plant genetics, and reproductive engineering with biochemistry, while facilitating in-depth discussions on the latest advancements in the field.

Yoshiko Murata (Suntory Foundation for Life Sciences, Bioorganic Research Institute)
Teruyuki Komatsu (Chuo University)
Michio Suzuki (The University of Tokyo)
Kota Takeda (AIST)
Hitomi Sawai (Osaka Metropolitan University / National Institutes f Natural sciences)

Organisms have utilised metal ions to sustain life throughout their four-billion-year history. Since the mid-20th century, research has focused on "understanding" the function and structure of metalloproteins. Today, through interdisciplinary collaborations, particularly with biochemistry, data on biometal-related molecules have accumulated. This wealth of knowledge has driven us to a stage where we can not only understand individual molecular mechanisms but also develop practical applications aimed at addressing global challenges, such as diseases, food crises, and environmental issues. This symposium introduces up-and-coming researchers who have made significant strides in utilizing biochemical research on biometals to devise innovative solutions for global issues, and discusses the "manipulation" of biometals.

Makoto Tachibana (The University of Osaka)
Jun-ichi Nakayama (National Institute for Basic Biology)
Takashi Fukaya (The University of Tokyo)
Yukako Hattori (Kyoto University)
Tatsuro Takahashi (Kyushu University)
Yukiko Gotoh (The University of Tokyo)

Chromatin serves as the structural framework for compacting genomic DNA and plays a crucial role in regulating gene expression. The nucleosome, the fundamental unit of chromatin, is composed of DNA and histones and interacts with various macromolecules to modulate genome activity. The structure of chromatin varies across different cell types and states, and its disruption can lead to a range of diseases. In this symposium, we will present research focused on understanding chromatin, which underpins cellular functions and constitutes the foundation of the 'Epicode' that governs cell fate.

Koutarou Nishimura (The University of Osaka)
Tsuyoshi Konuma (Yokohama City University)
Keisuke Yamamoto (The University of Tokyo)
Yoshihisa Kobayashi (National Cancer Center Research Institute)
Miwa Tanaka (The Cancer Institute)
Nobuyuki Kakiuchi (Kyoto University)

This symposium convenes emerging leaders in cancer research to present cutting-edge findings from genomics to organ-level interactions. We aim to foster interdisciplinary discussions on clonal evolution, inter-organ communication, and therapeutic applications based on advances in protein structure, RNA regulation, and chromatin dynamics. This comprehensive approach, spanning multiple biological scales, seeks to deepen our understanding of cancer's complex survival mechanisms and inspire innovative treatment strategies, befitting our centennial celebration.

Soichiro Fukada (The University of Osaka)
Takashi Shichita (Institute of Science Tokyo)
Aiko Sada (Kyushu University)
Shinji Tanaka (The University of Tokyo)
Mashito Sakai (Nippon Medical School)

Regeneration and repair after tissue injury are essential for tissues to regain homeostasis and function. Failure of tissue repair leads to chronic inflammation and the development of various pathological conditions, including age-related diseases. While the process of inflammation after injury is relatively common, the process of tissue repair is unique to each organ and reflects the regenerative and reparative potential. It has becoming clear that the process involves multiple cell types and their complex interactions. In this symposium, we would like to present and discuss the latest research findings on cell-cell interactions and their mechanisms governing tissue repair and homeostasis.

Takeshi Sakurai (University of Tsukuba)
Koji Ode (The University of Tokyo)
Takafum Minamimoto (National Institutes for Quantum Science and Technology)
Kenta Terai (Tokushima University)
Masao Doi (Kyoto University)

Biochemistry demonstrates its tremendous power when biochemical parameters determined in vitro explain physiologic phenomena occurring in vivo. Imaging of biochemical signals within living organisms serves as a pivotal foundational technology that facilitates such observations and discoveries. Here, we will introduce the latest research employing approaches to visualize biochemical signals that govern sleep and brain physiology. This includes FRET probes for imaging kinase and G-protein activity fluctuations, neuro-modulation imaging using GRAB sensors, membrane potential imaging using voltage-sensitive fluorescent proteins, and non-invasive brain imaging using MRI.

Uchida Syusaku (Nagoya City University)
Maekawa Motoko (Tohoku University)
Tomoyuki Furuyashiki (Kobe University)
Soichiro Ide (Tokyo Metropolitan Institute of Medical Science)
Makoto Arai (Tokyo Metropolitan Institute of Medical Science)
Mikio Hoshino (National Center of Neurology and Psychiatry)

Living organisms have resilience against various stressors. In modern human society, human-specific social stresses such as overwork, lack of exercise and sleep, and home and educational environments, are rapidly spreading, and various diseases caused by social stress have become a global problem. This symposium will introduce research results that elucidate the pathological mechanisms of stress-related diseases across multiple levels, from genes and cells to the mind and society, and lead to the development of diagnosis, prevention, and treatment. This symposium will build a new collaborative system to integrate basic medicine, life sciences, psychiatry, and psychology.

Yuta Hiraike (The University of Tokyo)
Kazuki Hattori (The University of Tokyo)
Phillip Dumesic (University of California)
Takako Chikenji (Hokkaido University)
Masaji Sakaguchi (Kumamoto University)
Chisayo Kozuka (RIKEN)

Obesity and type 2 diabetes are risk factors for cardiovascular disease and certain types of cancer. Comprehensive data analysis using biobanks, multi-omics, and machine learning are powerful methodologies for understanding phenotypes and generating hypotheses. However, biochemical approaches remain indispensable for understanding and validating the mechanisms. Here, emerging scientists will share novel concepts in the mechanisms of diabetes and obesity, including the regulation of energy metabolism via privileged mRNA translation, the role of cellular senescence and inter-organ network, epigenome-mediated obesity inheritance, 3D culture system, and machine learning-based prediction of insulin resistance. We aim to foster open discussions and future collaborations.

Yuichi Shichino (RIKEN)
Hotaka Kobayashi (Tokushima University)
Yoshitaka Matsuo (The University of Tokyo)
Bin Wu (Johns Hopkins University)
Arnaud Hubstenberger (iBV)

It is often assumed that the amount of RNA within a cell strongly correlates with the amount of protein. However, recent studies have revealed that this is not always the case. In fact, RNA undergoes a wide range of regulation during the translation process, meticulously determining the final quantity and quality of synthesized proteins. These findings have been brought to light through the advent of new technologies for analyzing RNA and translation. In this symposium, we aim to broadly introduce the latest techniques in RNA research, the discoveries made through them, and the new concepts being proposed.

Masaharu Somiya (The University of Osaka)
Natsuko Miura (Osaka Metropolitan University)
Keisuke Motone (The University of Osaka)
Satoshi Abe (Kyoto Prefectural University)
Koji Ooka (The University of Tokyo)

Advances in information science, especially deep learning/AI, and the development of large-scale analysis methods have dramatically advanced biomolecular design technology. Designed biomolecules are important not only for social needs, such as applications in medicine and engineering, but also for their contribution to life science research. The aim of this symposium is to bring together frontrunners in Japan on biomolecular design. We would like to discuss the current status and the future direction of biomolecular design with the audience.

Atsushi Kumanogoh (The University of Osaka)
Sho Yamasaki (The University of Osaka)
Junichi Kikuta (Kobe University)
Osamu Takeuchi (Kyoto University)
Peter Murray (Max Planck Institute of Biochemistry)

Inflammation is induced not only by exogenous stresses such as infection but also by endogenous stresses and is involved in many diseases. Various mechanisms regulate inflammation, and we would like to discuss frontline research in controlling inflammation from the point of view of multiple layers including molecular metabolism, cells, and organ relationships.

Shigeomi Shimizu (Institute of Science Tokyo)
Satoshi Goto (Rikkyo University)
Akihiro Harada (The University of Osaka)
Aya Mizuike (National Institute of Infectious Diseases)
Natsuko Jin (Hiroshima University)
Kanae Sasaki (University of Hyogo)

The Golgi is an important organelle responsible for post-transcriptional modifications and cargo sorting. In addition, the Golgi has a wide variety of functions, including lipid synthesis, stress response, exchange transport with other organelles, and proteolysis. How is the multifunctionality of the Golgi regulated? For many years, organelles were thought to be uniform structures compartmentalized by membranes. However, with the recent dramatic development of imaging technology including super-resolution microscopy, the concept of “organelle zones," localized functional regions within an organelle, has been proposed. This symposium will focus on the “Golgi functional zones", introduce the latest findings on their functions and regulatory mechanisms of the formation, and discuss the physiological significance and new aspects of these zones.

Takeshi Yoneshiro (Tohoku University)
Kaori Hayashi (Keio University)
Koshi Hashimoto (Dokkyo Medical University)
Joji Kusuyama (Institute of Science Tokyo)
Yuta Takahashi (Kumamoto University)

Epigenetics involves mechanisms like DNA methylation and histone modifications that regulate gene expression. These processes shape the epigenome, established early in life, which may influence the risk of lifestyle diseases such as obesity, hypertension, type 2 diabetes, and chronic kidney disease. The "Developmental Origins of Health and Disease (DOHaD)" hypothesis is supported by the Dutch Hunger Winter study, linking prenatal nutritional deprivation to a higher risk of such diseases in offspring.Emerging evidence shows paternal environmental factors can influence offspring epigenomes, with epigenetic changes potentially passing across generations, highlighting the need for early interventions. Biomarkers for identifying individual epigenome states may enable preventive medicine. This session examines these findings from varied perspectives.

Daniel J Finley (Harvard Medical School)
Kylie J Walters (National Cancer Institute)
Min Jae Lee (Seoul National University)
Eri Sakata (Georg-August-Universitat Gottingen)
Yasushi Saeki (The University of Tokyo)
Shigeo Murata (The University of Tokyo)

The composition and abundance of thousands of proteins determine cellular function. Protein degradation, along with synthesis, plays a key role in shaping the proteome. Protein homeostasis is maintained by balancing synthesis and degradation. During processes such as cellular differentiation or functional changes, the protein composition must be reconfigured. While changes in synthesis are well documented, proteolysis also undergoes dynamic shifts. However, the mechanisms of selective and large-scale proteolysis remain unclear. This symposium presents the latest findings on proteome remodeling and novel proteolysis process mechanisms.

Fumiaki Ohtake (Hoshi University)
Shuya Fukai (Kyoto University)
Yusuke Sato (Tottori University)
Michael Rape (UC Berkeley)
Brenda Schulman (Max Planck Institute of Biochemistry)

Ubiquitin regulates various cellular processes such as protein degradation, signal transduction, and proteostasis maintenance. The functional diversity of ubiquitylation based on its architecture is referred to as the ubiquitin code. However, the whole picture of the regulatory mechanism for the ubiquitin code has long remained enigmatic. Recent technological advances in structural biology and proteomics have facilitated deeper understanding of the detailed molecular mechanisms for writing, erasing, and decoding the ubiquitin code. In this symposium, we will discuss these leading-edge research topics together with Dr. Michael Rape and Dr. Brenda Shulman, who are top scientists in the research field of the ubiquitin code.

Richard Youle (National Institute of Health)
David Komander (Walter and Eliza Hall Institute of Medical Research)
Waka Kojima (Institute of Science Tokyo)
Tatsuro Maruyama (Institute of Microbial Chemistry)
Daisuke Morito (Showa University)

Cells are highly compartmentalized by a diverse array of membranous and non-membranous organelles, enabling them to control, coordinate, and integrate numerous biological processes simultaneously. Organelles, including non-membranous liquid droplets, are not merely static structures but dynamic functional entities that undergo continuous formation, transformation, and degradation. This symposium will explore the dynamics of organelles, with a particular focus on the mechanisms governing their lifespan and degradation. We are pleased to host two distinguished international speakers who will provide insights into current hot topics in this field.

Noriyuki KiKioka (Kyoto University)
Nozomu Kono (University of Tokyo)
Junichi Ikenouchi (Kyushu University)
Isao Naguro (The University of Tokyo)
Kyoichiro Tsuchiya (University of Yamanashi)
Satoshi Kuwana (University of Tokyo)

Research on molecular mechanisms of “cell structure and function," including cell adhesion, cell migration, and morphology of cell and cell membrane, has progressed rapidly, partly due to the development of comprehensive analysis and imaging techniques. In the course of these research, it has become clear that “cell structure and function" are deeply related to “metabolism," which is the basis of biochemical research. In this symposium, we will discuss how metabolism affects the structure and behavior of cells and, conversely, how the structure and behavior of cells regulate metabolism, including the relationship with diseases and studies using model organisms.

Katsumi Maenaka (Hokkaido University)
Hikaru Koga (Chugai Pharmaceutical Co.,Ltd.)
Mitsuo Umetsu (Tohoku University)
Yoshimasa Kawaguchi (Kyoto University)
Yuji Ito (Kagoshima University)

Antibody drugs have established their position as therapeutics for diseases, particularly cancer and autoimmune diseases, but various developments are still ongoing to establish treatments for difficult-to-treat diseases. Among them, we planned and organized this symposium focusing on new approaches to drug discovery by antibody engineering. We would like to discuss the possibilities of new drug discovery based on these approaches, including future prospects.

Jun Suzuki (Kyoto University)
Kazuhiro Abe (Hokkaido University)
Kenta Moriwaki (Hiroshima University)
Ayumu Sumino (Kanazawa University)
Hsin-Yung Yen (Academia Sinica)

In recent years, advances in genetic and biochemical screening techniques have begun to identify new aggregates that are constructed at the cell membrane. Those assemblies not only regulate ion and lipid dynamics, but also determi the fate of cell life and death. This symposium aims to bring together top researchers in the field of plasma membrane assembly to share the latest findings and discuss them with the audience.

Mieko Arisawa (Kyushu University)
Michito Yoshizawa (Institute of Science Tokyo)
Akiyuki Nishimura (National Insitute for Physiological Sciences / Exploratory Research on Life and Living Systems)
Tianli Zhang (Akita University)
Hiroaki Fujita (Kyoto University)
Yoshiaki Furukawa (Keio University)

Redox reactions in living organisms support various higher-order functions. However, redox biomolecules are unstable and short-lived, meaning that the actual forms present in vivo may not always correspond to their structures as currently recognized. These are collectively referred to as redox supermolecules. Research has focused on the exploration of novel redox supermolecules, particularly supersulfides, and the analysis of their chemical properties. This symposium will present the latest findings on the metabolism, biological functions, and medical applications of redox supermolecules.

Kenji Inaba (Kyushu University)
Motomasa Tanaka (RIKEN)
Ryo Ushioda (Kyoto Sangyo University)
Keiko Kono (Okinawa Institute of Science and Technology Graduate University)
Izumi Yanatori (Kyoto University)
Shin Mizukami (Tohoku University)

The chemical environment in cells is strictly controlled in each compartment. However, the mechanism by which this control occurs remain unclear. Interestingly, it has become clear that chemical parameters are not controlled independently in each compartment, but crosstalk occurs between compartments, and that organelles communicate with each other via biomolecules. Therefore, we are planning a symposium to clarify a precise map of the intracellular chemical environment (named a "chemical atlas") and to understand how its homeostasis (chemical homeostasis) controls cellular functions through its connection with proteostasis and organellastasis.

Kazuhiko Igarashi (Tohoku University)
Takeshi Inagaki (Gunma University)
Akiko Takahashi (Japanese Foundation for Cancer Research)
Yosuke Tashiro (Shizuoka University)
Shinya Toyokuni (Nagoya University)
Toshiro Moroishi (Institute of Science Tokyo)

Iron is the most abundant element by weight on Earth and has long been recognized for its involvement in a wide range of biochemical reactions in living organisms, primarily as a cofactor for various enzymes. Recent research has shown that intracellular iron homeostasis actively regulates the activity of numerous enzymes. The role of iron in critical cellular processes, such as cell proliferation, cell death (known as ferroptosis), and cell differentiation, is gradually being uncovered. This symposium will provide an overview of the new biological functions of iron in the diverse contexts of life, aging, disease, and death. We will discuss the molecular networks regulated by iron, their physiological and pathological significance, and explore the future prospects of iron biochemistry.

Shigeki Higashiyama (Osaka International Cancer Institute)
Naohiko Koshikawa (Institute of Science Tokyo)
Yoko Kimura (Shizuoka University)
Masayuki Shimoda (The Jikei University School of Medicine)
Kyoko Shirakabe (Ritsumeikan University)
Koh Nakayama (Asahikawa Medical University)

Proteins released from cells are processed in multiple ways to acquire normal function. Meanwhile, changes in extracellular environment induce cellular stress and alter protein processing resulting in accumulation of abnormal proteins, which eventually cause diseases. Further, cells derived from diseases, such as cancer cells, produce irregular proteins and involved in pathological state. In this symposium, we will overview the protein processing: translation, post-translational modification, and shedding. From these aspects, we will seek for the ways to utilize abnormal proteins as biomarkers.

Yoko Ito (Ochanomizu University)
Toshiaki Izawa (University of Hyogo)
Jun Arii (Kobe University)
Tatsuya Tago (Hiroshima University)
Yuta Amagai (Kyushu University)
Satoshi Ninagawa (Kobe University)

The release of substances into the extracellular environment is vital for organismal survival, yet it also facilitates pathogen spread, as seen in viral budding. During these processes, cells rigorously monitor the quality and condition of molecules designated for secretion, employing mechanisms to degrade or remove inappropriate or damaged molecules and to sort and transport properly synthesized proteins to their destinations. Notably, viruses exploit these cellular systems to achieve extracellular release. This symposium will highlight molecular mechanisms from protein synthesis to extracellular release, focusing on secretion in yeast, plant, and animal cells, as well as the role of virus budding. Leading researchers will share the latest findings and discuss future perspectives in this field.

Masamitsu Konno (AIST)
Sikun Meng (The University of Osaka)
Takahito Ohshiro (The University of Osaka)
Akiko Ogawa (Tohoku University)
Ryoma Yoneda (Saitama Medical University )
Atsushi Fujimura (Kagawa University)
Shotaro Tatekawa (The University of Osaka)
Takehisa Watanabea (Kumamoto University)

RNA chemical modifications serve as pivotal regulators not only in somatic cells but also in the phenotypes of stem cells and various diseases. These modifications orchestrate complex interactions of critical biological processes, including mRNA synthesis and degradation, splicing, translation initiation and elongation, tRNA decoding efficiency, miRNA-mediated gene silencing, epigenetic scaffolding, and even radiotherapy resistance. Their profound impact has also paved the way for new frontiers in drug discovery and development. This symposium serves as a premier platform to showcase and discuss cutting-edge advancements in RNA modification research.

Eri Kawashita (Kyoto Pharmaceutical University)
Satoshi Hirohata (Okayama University)
Chiaki Maruyama (Tokyo Metropolitan Institute of Medical Science)
Eri Wada (Nagoya University)
Tang-Long Shen (National Taiwan University)
Hiroshi Hasegawa (Kobe Pharmaceutical University)

The extracellular environment surrounding cells is composed of various extracellular factors, including extracellular matrix, growth factors, extracellular proteases involved in the processing of these factors, and exosomes, which regulate cellular morphology, migration, growth, and differentiation. This symposium will focus on how the extracellular environment influences cellular responses in various organs and contributes to physiological functions as well as the onset and progression of diseases. The goal of this symposium is to develop a comprehensive understanding of the role of the extracellular environment in biological phenomena and disease mechanisms resulting from its disruption. Therapeutic approaches targeting the extracellular environment will also be discussed to explore potential avenues for the development of new disease treatments.

Michiaki Hamada (Waseda University)
Mayuko Izumi (The University of Osaka)
Hung-Ya Tu (The University of Osaka)
Alexis Vandenbon (Kyoto University)
Ryoichi Mori (Nagasaki University)
Hisamichi Naito (Kanazawa University)

Recently, single-cell multiomics analysis has become a powerful tool for elucidating biological phenomena. Today, approaches that integrate single-cell analysis with other modalities, including chromatin structure, spatial transcriptomics, and imaging, are emerging with ongoing advancements in various research methodologies. However, the effective leveraging of the vast and often overwhelming amount of modality data to progress research remains a significant challenge for many researchers due to its complexity. In this symposium, we invited emerging young researchers from diverse fields of multi-omics studies to share their latest and original findings. By exploring ongoing cutting-edge insights, we aim to foster a discussion with participants about the new possibilities that single-cell multimodal analysis and integrated modality approaches can offer.

Asuka Inoue (Kyoto University)
Ka Young Chung (Sungkyunkwan University)
Arun Shukla (Indian Institute of Technology)
Xiangyu Liu (Tsinghua University)

Arrestins are crucial regulators of GPCR signaling, involved in desensitization and signaling pathways distinct from G proteins. While phosphorylated GPCRs and lipid membranes are known to alter structures and functions of arrestins, overall regulatory mechanism remains unclear. This symposium gathers leading Asian GPCR researchers to explore arrestin function through tool development, structural analysis, biochemistry, and cellular studies. We aim to enhance our understanding of arrestin-mediated GPCR signaling regulation and advance the development of arrestin-selective "biased" GPCR agonists. Join us to uncover new insights into this fundamental process and its therapeutic potential.

Yuhkoh Satouh (Gunma University)
Yui Jin (The Nippon Dental University)
Takahiro Chihara (Hiroshima University)
Tatsuo Miyamoto (Yamaguchi University)
Akiko Satoh (Hiroshima University)
Seiichi Koike (University of Toyama)

Controlled membrane trafficking within cells is not only essential for maintaining the functions of organelles but also for regulating processes at the organismal level. Disruption of this process can lead to various diseases. However, experiments using cultured cell lines alone are insufficient to fully elucidate the functions of membrane trafficking. It is crucial to conduct research using specialized cells with unique intracellular structures.In this symposium, researchers utilizing unique cell models to investigate various cellular phenomena from the perspective of membrane trafficking will present their recent findings. Topics include recent discoveries on organelle formation using yeast, the relationship between membrane trafficking and developmental processes, and efforts to uncover the pathology of ciliopathies and neurodegenerative diseases using mouse and Drosophila.

Hiroyuki Hosokawa (Tokai University)
Kazuko Saeki (Juntendo School of Medicine)
Takayo Yanagawa (Tokai University)
Naofumi Funagura (Kumamoto University)
Hiroshi Kimura (Tokai University)
Yasutaka Motomura (Tokyo University of Science)

Metabolism refers to a series of biochemical reactions occurring within living organisms and is essential for sustaining life. Metabolism is a fluctuating system, dynamically changing in response to external and internal factors. Recent findings have highlighted the heterogeneity of metabolism, as well as its role as a mediator across multiple levels such as intracellular, intercellular, and inter-organ interactions. Consequently, increasing attention is being paid to the concept of "metabolic fluctuations." In this symposium, we will focus on the fluctuations of metabolic systems and discuss how they influence individual "constitutions" and contribute to disease and immune defense responses. We have invited five leading researchers to present the latest findings on the spatiotemporal interactions of metabolic systems in disease and immune responses and their impact on the constitution.

Kazuhiro Hayashi (Ministry of Education, Culture, Sports, Science And Technology)
Leslie McIntosh (Digital Science)
Takashi Sutani (The University of Tokyo)

AI is an essential tool in future research activities; however, the expansion of "Fake Science" through AI could undermine the trust in research. Researchers' responsibilities to society have recently gained attention within the context of "Responsible Research and Innovation." As part of this trend, the practice of "Open Science" is being encouraged. Producing trustworthy research through a highly transparent process is also crucial for us to build an appropriate relationship with AI. In this symposium, we will discuss the current state and prospects of Open Science and explore how researchers should be in the future with the audience.

Shigehiro Kawashima (The University of Tokyo)
Gosuke Hayashi (Nagoya University)
Suguru Hatazawa (The University of Tokyo)
Kiyoe Ura (Chiba University)
Takashi Umehara (RIKEN)
Yohsuke Fukai (RIKEN)

Post-translational modifications (PTMs) of proteins are important for the regulation of biological responses. To directly and quantitatively understand the significance of these PTMs, the key is how to prepare proteins with PTMs introduced at specific amino acid residues in high purity and in large quantities. In this regard, various technological innovations in chemistry and biochemistry have been made in recent years. In this symposium, we will focus on histones as the subject of proteins and introduce the state-of-the-art in the study of chromatin modification. The symposium aims to promote mutual understanding at the field level of Chem-Bio and the fusion of different fields from the viewpoint of advantages and disadvantages of chemistry and biochemistry and what can be done with them.

Soo-Youl Kim (National Cancer Center Korea)
Hideki Tatsukawa (Nagoya University )
Kayo Sugitani (Kanazawa University)
Katsumitsu Shimada (Matsumoto Dental University)
Qin Xian-Yang (RIKEN)
Masayoshi Souri (Yamagata University)

Transglutaminase is an enzyme family that catalyzes cross-linking reaction in various proteins. This reaction is involved in several biological events, such as blood coagulation, apoptosis and skin formation. The catalytic activity is strictly regulated and the aberrant activity causes diseases. Several investigations have been developed with regard to the regulatory mechanisms of the expression and activity as well as physiological functions. In this symposium, we would like to shed light on biological events for the enzyme to contribute to maintenance of homeostasis and to clarify the mechanism of diseases, in various tissues and cell system.

Pattama Wiriyasermkul (Iwate University)
Ayako Takeuchi (Fukui University)
Takuto Fujii (Toyama University)
Masayuki Iwamoto (Fukui University)
Haruo Ogawa (Kyoto University)

Membrane transport proteins, including ion channels, transporters, and ATPase, play vital roles in life by regulating cellular activities and maintaining homeostasis by transporting ions, nutrients, and metabolites across cell membranes. This symposium highlights the importance of these proteins in physiological functions and pathological relevance. By gathering leading experts and employing cutting-edge technologies in systems biology, cellular and molecular analysis, and single-molecule analysis, the symposium explores the roles of membrane transport proteins from the body level to the molecular level. The symposium will deepen our understanding of life's functions, fostering discussion among participants across diverse environmental contexts while highlighting future directions and innovations to illuminate further the roles of these proteins in living organisms.

Kanae Ando (Tokyo Metropolitan University)
Miho Terunuma (Niigata University )
Hiroshi Onishi (Gunma University)
Atsushi Saito (Kanazawa University)
Sho Inami (Thomas Jefferson University)

Cells are equipped with mechanisms that maintain homeostasis in response to stressors. Such responses provide resilience at animal levels, such as stress tolerance and recovery. However, these cellular responses alter with aging or disease. In addition to the primary triggers of aging and disease, declines in homeostasis caused by such remodeling of the cellular responses serve as a secondary yet essential factor contributing to the pathogenesis. Through the latest findings on the alterations in the intracellular environment, signaling, and stress responses in aging and disease, this symposium aims to discuss their roles in resilience and potential therapy.

Yuka Inaba (Kanazawa University)
Miyako Tanaka (Nagoya University)
Manami Oya (Nagoya University)
Satoko Arai (The Institute for AIM Medicine)

Food is essential for life, with nutrient intake and energy metabolism governed by finely tuned molecular mechanisms operating from the cellular to the systemic level. However, in this era of overnutrition, characterized by significant changes in both the quantity and quality of diet, the dysregulation of these systems has contributed to metabolic disorders and accelerated aging, fostering the perception of food as a "double-edged sword." This symposium aims to promote a deeper understanding of "diet-driven pathophysiology" by showcasing cutting-edge research from experts across diverse fields. Through these insights, we will explore the mechanisms that regulate homeostasis and those that lead to its dysregulation.

Yoriko Atomi (Teikyo University)
Kaori Takahashi (Tohoku University)
Noriyuki Okudaira (Teikyo University)
Naoki Ito (National Center for Geriatrics and Gerontrogy)
Akihisa Mitani (The University of Tokyo)
Miho Shimizu (Teikyo University)

Humans, as multicellular organisms, can modify lifestyle and behavior based on scientific knowledge. Our cells adapt through activity-dependent survival strategies. Providing them with proper nutrition and stimulation promotes health and longevity. To extend a healthy lifespan, lifestyle habits must prevent locomotive syndrome, metabolic syndrome, dementia, and cancer. Yet, research on diet and exercise has lagged behind, as they mainly support fundamental cellular housekeeping. Their biochemical mechanisms remain insufficiently explored. This symposium integrates cellular and systemic biochemistry to examine the cooperation of organs, tissues, and cells in "eating, moving, and breathing." By discussing molecular and biochemical insights, we aim to establish scientific frameworks for optimizing lifestyle interventions and promoting longevity.

Kazutoshi Kasho (Kyushu University)
Yoshitaka Kawasoe (Kyushu University)
Hisao Masai (Tokyo Metropolitan Institute of Medical Science)
Yoshizumi Ishino (Kyushu University)
Asako Furukohri (The University of Osaka)
Yuji Masuda (Nagoya University)
Miki Shinohara (Kindai University)

Genetic information in chromosomes is properly inherited by daughter cells through DNA replication, repair, and recombination. With the current development of various genomics analysis methods, in vitro reconstitution, and microscopy techniques, it is becoming clear that the dynamic chromosomal structures (such as DNA supercoils, G-quadruplexes, repetitive sequences, loop formation, nucleoids, etc.) play important regulatory roles in the gene expression, replication, and homeostasis. However, due to the difficulty of analyzing the regulation coupled with the higher-order structure of chromosomes, it has not yet been possible to clarify the common principles across biological species. In this symposium, we will introduce cutting-edge research on the regulation of DNA replication, repair, and recombination to understand the common principles.

Michiko Shirane (Nagoya City University)
Sayaka Takemoto-Kimura (Nagoya University)
Hiroshi Kawasaki (Kanazawa University)
Takeshi Imai (Kyushu University)
Makoto Kondo (Osaka Metropolitan University)
Mitsuru Ishikawa (Fujita Health University)

In this symposium, we'll discuss the latest topics in neuroscience such as development of cutting-edge technologies and exploring new research areas. The forefront technology includes dynamic connectome analysis that reveals the entire picture of brain neural circuits, method using ferrets as model animals close to the human brain, and technology that directly induces nervous system cells from stem or somatic cells. New research areas include mechanism underlying emotional regulation by lipid metabolism, calcium signaling of neural circuit in neurodevelopmental disorders, and antidepressant effects by exercise.

Koichi Iijima (National Center for Geriatrics and Gerontology)
Akinori Miyashita (Niigata University)
Tadafumi Hashimoto (National Center of Neurology and Psychiatry)
Yu Yamazaki (Hiroshima University)
Hirotaka Watanabe (Keio University)
Hiroki Sasaguri (RIKEN)

Apolipoprotein E (APOE) plays a critical role in the pathogenesis of Alzheimer's disease (AD). The three APOE alleles (ε2, ε3, ε4)encode protein isoforms that differ at two amino acid positions, and the ε4 allele (APOE4) is a strong risk factor for AD. Anti-amyloid-β (Aβ) immunotherapies show adverse effects in the form of cerebrovascular damage, and APOE4 is a major risk factor for this side effect. Since APOE4 carriers represent a large population of AD patients, it is crucial to develop APOE-targeted therapy for AD. APOE is also involved in hyperlipidemia, cardiovascular and metabolic diseases, and interaction with these research communities will create a synergetic effect. In this symposium, experts on APOE in AD research will present and discuss the future direction of AD therapeutic.

TBA

Aging signals and metabolic stress form intricate networks that extend beyond cellular senescence, shaping aging at organ and organismal levels and contributing to the onset and progression of various diseases. Homeostatic mechanisms within cells and molecules are closely tied to aging, immune responses, and cancer, and their failure underlies many pathological conditions. Advances in single-cell analysis, spatial transcriptomics, and proteomics now offer dynamic, multidimensional insights into these complex networks across cells and organs. This symposium convenes researchers investigating aging, disease, and life processes from neuroscience, metabolism, immunology, and genetics perspectives. By exploring innovative studies on the interactions between aging, disease progression, and homeostatic regulation, we aim to enhance our understanding of these interconnected phenomena.

Hiyoshi Hirotaka (Nagasaki University)
Nozomu Obana (Tsukuba University)
Yoshiyuki Goto (Chiba University)
Shinya Watanabe (The Jichi Medical University)

This symposium aims to reaffirm the crucial role of bacteria and microorganisms in understanding the principles of life and to highlight the forefront of microbiological research. It will explore the structure, physiology, ecological roles, and evolutionary significance of microorganisms from both basic and applied perspectives.Advances in genome analysis and single-cell technologies have revealed the intricate interactions between microorganisms, multicellular organisms, and the environment, offering new insights across life sciences. This symposium will bring together leading researchers in Japan to discuss the current state and future directions of microbiology, fostering interdisciplinary collaboration.

Liesbeth Veenhoff (University of Groningen)
Naoko Imamoto (Jikei University of Health Care Sciences)
Shingo Kose (RIKEN)
Tokuko Haraguchi (The University of Osaka)
Richard Wong (Kanazawa University)

The nuclear pore complex (NPC) is the sole gateway between the nucleus and cytoplasm, mediating selective transport of proteins, RNA, and small molecules. Its dynamics influence key biological processes such as gene regulation, genome integrity, differentiation, and viral infection. Recent HS-AFM studies have revealed real-time NPC structural changes during transport. This session covers NPC structural dynamics, nuclear-cytoplasmic transport mechanisms, NPC-related diseases, and viral nuclear entry, incorporating HS-AFM data and AI-based analysis. We will also explore NPC-mediated transport selectivity and its interplay with epigenetic regulation. Our goal is to enhance understanding of NPC function and inspire new research directions.

Ritwick Sawarkar (University of Cambridge)
Nadinath Nillegoda (Monash University)
Eisuke Itakura (Chiba University)
Tomohide Saio (Tokushima University)
Ami Sugisawa (Kyoto Sangyo University)

The concept of molecular chaperones was defined in the late 1980s based on their function in assisting protein folding and is now well established as essential factors supporting the life of proteins in the cell and protein homeostasis (proteostasis). However, it has recently become clear that chaperones play roles beyond the conventional paradigm, such as binding to RNA and being directly involved in liquid-liquid phase separation. In this symposium, we would like to provide an opportunity for researchers working on chaperones beyond the conventional view to introduce and discuss the new paradigm of chaperones.

Hiroshi Nishimasu (The University of Tokyo)
Osamu Nureki (The University of Tokyo)
Makoto Saito (RIKEN)
Kazuki Kato (Institute of Science Tokyo)
Kotaro Kiga (National Institute of Infectious Diseases)

Enzymes in nature exhibit remarkable diversity and are essential for maintaining biological functions. Extensive studies over the past two decades revealed that diverse CRISPR-Cas enzymes work together with cognate RNA guides to defend against foreign nucleic acids. Following the discoveries of Cas9, Cas12, and Cas13, new enzymes have been identified. Furthermore, recent studies identified ancestors of Cas enzymes and eukaryotic homologs. Recent studies also showed that prokaryotes use a variety of defense systems beyond CRISPR-Cas to combat viruses. This symposium will present the forefront of basic research and applied technologies of these new enzymes.

Makoto Arita (Keio University)
Haruki Uchino (RIKEN)
Yasuhiro Murakawa (Kyoto University)
Kazuya Tsumagari (RIKEN)
Hiroshi Tsugawa (Tokyo University of Agriculture and Technology)

Molecular diversity of lipids makes it highly likely that unknown functions will be discovered. In addition, abnormal lipid metabolism is a background factor in many diseases, which may lead to the discovery of new drug seeds and early diagnosis and treatment. In this symposium, we will introduce the latest findings of spatial multilayer omics approach aimed at elucidating the mechanisms that create, regulate and recognize lipid diversity and its localization in vivo.

Takanobu Katoh (The University of Tokyo)
Issei Shimada (Nagoya City University)
Maki Takagishi (Nagoya City University)
Taro Chaya (The University of Osaka)
Saishu Yoshida (Toho University)

Cilia are organelles that protrude from the cell surface and play important roles in the development and homeostasis. Dysfunctions of cilia not only cause congenital diseases called ciliopathies but also are implicated in cancer and aging. In recent years, the development of analytical methods based on the integration of various research fields including biochemistry has taken the elucidation of the functional mechanisms of cilia to a new dimension. In this symposium, we will present the latest findings in cilia biology revealed by state-of-the-art methods including omics analysis, organoids, advanced measurement techniques, and 3D microscopic manipulation techniques, as well as the therapeutic strategies that have emerged from the elucidation of the mechanisms underlying ciliary function.

Masaoki Kawasumi (University of Washington)
Hironobu Ikehata (Tohoku University)
John Wyrick (Washington State University)
Shiyong Wu (Ohio University)
Akira Nagatani (Kyoto University)
Chikako Nishigori (Kobe University)
Tadamichi Shimizu (University of Toyama)
Jun Muto (Ehime University)

Photobiology is the study of the relationship between light and life and has a long history. The biological effects of different wavelengths of light are diverse, and it is well known that UV-induced genetic mutations can lead to skin cancer development. Recent technological advances have elucidated various cellular responses to visible light and UV radiation (DNA damage and repair, oxidative stress, gene expression, photoreception, signal transduction, the cell cycle, inflammation, and immunity) at the molecular level. This symposium will present cutting-edge research on the molecular mechanisms of biological response to light.

Kenichi Asano (Yokohama City University)
Tomoaki Koga (Kumamoto University)
Takuji Suzuki (Chiba University )
Hirotaka Masuda (Kyushu University)
Shinya Suzu (Kumamoto University)

Recent technologies such as single-cell RNA sequencing have revealed that macrophages consist of multiple subsets with distinct origins and functions. Despite these advances, many studies remain focused on clustering these subsets based on gene expression profiles, with limited exploration into their roles in maintaining tissue homeostasis or driving disease progression. This symposium aims to bridge this gap by shedding light on the diverse and dynamic roles of macrophages in health and disease. By exploring macrophages from the perspectives of metabolism, infection, and tissue-specific functions, this event seeks to provide insights into the underlying mechanisms of various disease onset and resolution, which may promote interdisciplinary discussion and collaboration.

Atsushi Enomoto (Nagoya University)
Yukako Oda (Kyoto University)
Shimpei Kawaoka (Tohoku University)
Tomonori Yaguchi (Kyoto University)
Mizuho Nakayama (Kanazawa University)
Akihisa Fukuda (Kyoto University)

Malignant transformation of tumours progresses through the accumulation of mutations in the oncogenic cells, as well as through interactions with surrounding cells. Understanding these mechanisms is crucial for the regulating malignancy and advancing treatment strategies.In this symposium, researchers from diverse fields will present their latest research on the molecular mechanisms driving cancer progression and immune suppression. The session will provide a platform for discussing emerging concepts and unresolved questions, fostering collaboration and inspiring new approaches to cancer research and treatment development.

Satoshi Inoue (National Center for Geriatrics and Gerontology)
Akira Kobayashi (Doshisha University)
Hiroshi Suzuki (Nagoya University)
Mitsuyo Matsumoto (Tohoku University)
Reo Maruyama (The Cancer Institute)
Hiromi Yamazaki (The University of Osaka)

The molecular mechanisms underlying cancer cell heterogeneity, plasticity, and their ability to acquire therapy resistance remain significant challenges. In this symposium, we aim to focus on how deregulation or failure of transcription factors and chromatin regulators impacts gene expression, ultimately shaping the characteristics and behavior of cancer cells. We also explore how insights from multi-omics approach of various cancer can be leveraged to develop new therapy strategies. We believe we can strengthen research community, while exploring new directions for future advancements. Regarding diversity, speakers represent national and private universities as well as research institutes, cover three age groups, with both junior and senior investigators and two women scientists.

Ryotaro Nishi (Tokyo University of Technology)
Masataka Tsuda (National Institute of Health Sciences)
Rie Kanao (Nagoya University)
Masayuki Kusakabe (Kobe University)
Junpei Yamamoto (The University of Osaka)
Syota Matsumoto (The University of Tokyo)

Genetic information in organisms need to be accurately passed on their next generation, and DNA replication plays its fundamental role. However, genome DNA is constantly exposed to harsh environments that cause mutations. To avoid the risk, DNA repair machineries scan, recognize, and repair the damage on genome, ensuring the maintenance of genome integrity. Although these DNA replication and repair mechanisms have been investigated, there are still many aspects that remain ambiguous. In addition, treatment for patients with incurable diseases caused by hereditary deficiency in these machineries is under development. In this symposium, we would like to invite researchers from various fields who incorporate cutting-edge experimental methods and provide a forum for approaching the mechanisms.

Yusuke Hirabayashi (The University of Tokyo)
Jiyoung Mun (Korea Brain Research Institute)
Taeko Kobayashi (The University of Tokyo)
Naoya Murao (University of Miyazaki)
Sayako Katada (Kyushu University)
Dieter Chichung Lie (Friedrich-Alexander University)

The regulation of brain function depends on the pivotal roles of various organelles, including mitochondria, endoplasmic reticulum (ER), lysosomes, mitotic spindles, and extracellular vesicles (EVs). These organelles operate independently and synergistically to govern the activities of neural stem cells and neuronal cells. Deciphering the sophisticated mechanisms mediated by these organelles is crucial for understanding normal brain function and the pathological processes underlying age-related cognitive decline and neurodegenerative diseases. This symposium aims to provide a platform for introducing cutting-edge research on neural (stem) cells, highlighting the critical roles of organelles in maintaining brain function and addressing key challenges in neuroscience.

Ryoji Suno (Kansai Medical Universtiy)
Tsuyoshi Saitoh (University of Tsukuba)
Ayori Mitsutake (Meiji University)
Masataka Yanagawa (Kyoto University)
Hideaki Kato (the University of Tokyo)

G protein-coupled receptors (GPCRs) regulate diverse physiological processes and are targets for ~30% of approved drugs, making them vital in drug discovery. Structure-based drug design (SBDD) is a key strategy, but obtaining structural data has been time-consuming and costly. Advances in cryo-electron microscopy (cryo-EM) now enable rapid, high-resolution GPCR structural determination. Additionally, pharmacological analyses, molecular dynamics simulations, and single-molecule imaging have deepened insights into GPCR signaling. Integrating dynamic and static structural data with signaling activity is accelerating rational drug discovery. This symposium will showcase cutting-edge technologies driving GPCR drug development and their impact on next-generation therapeutics.

Keiko Yasumatsu (Tokyo Dental Junior College)
Eisuke Kato (Hokkaido University)
Shuhei Hosomi (Osaka Metropolitan University)
Anna Yoshimura (Kyushu Dental University)
Osamu Kaminuma (Hiroshima University)

Taste has evolved significantly to detect chemical substances, eliciting diverse responses and emotions under conscious awareness. Its role as one of the five senses has garnered considerable attention. However, taste receptors, often thought to be limited to their specific functions, such as Tas1r (sweet and umami) and Tas2r (bitter), are also expressed in the intestinal tract, bone, fat, and immune cells. These receptors sense environmental information like energy sources and nutrients, regulating development, differentiation, and functions. This raises the question: 'Why do we taste with our whole body?' This session, organized by pioneering researchers, aims to explore this question.

Tsuyoshi Osawa (The University of Tokyo)
Teppei Shimamura (Institute of Science Tokyo)
Hiroshi Asahara (Institute of Science Tokyo)
Ryo Yoshida (The Institute of Statistical Mathematics)
Yutaka Suzuki (The University of Tokyo)
Kazuo Takayama (Kyoto University)

Life sciences are advancing into unprecedented depths through revolutionary technologies and AI. Single-cell multi-omics illuminates molecular mechanisms, spatial omics reveals tissue architecture, and AI transforms molecular design and experimentation - marking a historic transformation. As these technologies merge to create new research frontiers, this symposium brings together emerging researchers integrating these advances. Through topics ranging from cancer omics to AI-driven systems biology and infectious disease models, young scientists will showcase the field's new directions.

Kaito Chikara (Okayama University)
Yasuhiko Matsumoto (Meiji Pharmaceutical University)
Atsushi Miyashita (Teikyo University)
Masaki Ishii (Musashino University)

Understanding host-pathogen interactions remains a critical challenge in infectious disease research. This symposium will showcase cutting-edge research approaches that combine biochemical and genetic analyses with non-mammalian model systems to investigate the relationships between pathogenic microorganisms (bacteria and fungi) and their hosts, leading to new perspectives in infection control. Through this symposium, we aim to demonstrate the importance of multifaceted approaches in understanding host-pathogen interactions and facilitate dynamic discussions on developing novel strategies for infection control.

Yasuhiko Kizuka (Gifu University)
Morihisa Fujita (Gifu University)
Naonobu Fujita (Institute of Science Tokyo)
Akira Yokoi (Nagoya University)
Daisuke Tsuji (Yasuda Women's University)

Approximately one third of proteins enter the secretory pathway, and most of them receive glycosylation in the endoplasmic reticulum and the Golgi apparatus, following transport to their destination organelles, plasma membrane and extracellular space. In addition to these classical pathways for modification, trafficking and secretion, novel endosome- and lysosome-mediated mechanisms of secretion and communication have been revealed, including secretion of extracellular vesicles (EVs) and lysosomal exocytosis. Moreover, as these organelles are highly involved in degradation, new endo/lysosome-based dynamic mechanisms are also suggested by which glycans and related molecules are released and degraded. In this symposium, researchers working on the regulation of glycans and related molecules by secretion and degradation will give their recent findings.

Mitinori Saitou (Kyoto University )
Azusa Inoue (RIKEN)
Ichiro Hiratani (RIKEN)
Anja Groth (University of Copenhagen)
Wei Xie (Tsinghua University)

Epigenetic inheritance and resetting are a foundation for the maintenance and differentiation of cellular phenotype, respectively. On the other hand, their anomalies lead to various diseases. This symposium brings together leading scientists elucidating the mechanism of epigenetic inheritance and resetting at the cellular and developmental levels and discusses their latest findings and their broad implications.

Yu Hayashi (The University of Tokyo)
Koji Yamanaka (Nagoya University)
Makoto Higuchi (National Institutes for Quantum and Radiological Science and Technology)
Yukiko Hori (The University of Tokyo)
Takashi Saito (Nagoya City University)

Aggregation and deposition of amyloid-β (Aβ) and tau have been recognized as an important pathological mechanism of Alzheimer disease (AD), the most common cause of dementia. In recent years, anti-Aβ antibody drugs have been approved as the treatment of AD. On the other hand, it has become clear that the efficacy of anti-Aβ antibody drugs is limited. There is therefore a need to develop new approaches to the prevention and treatment of AD. This symposium will present and discuss new developments in the future of dementia research by researchers who are elucidating new pathogenic mechanisms and developing innovative diagnostic, preventive, and therapeutic techniques for dementia.

Ikuo Kimura (Kyoto University)
Hiroshi Ohno (RIKEN)
Hisako Kayama (The University of Osaka)
Satoshi Uematsu (Osaka Metropolitan University)

It is becoming clear that the intestinal bacteria (microbiome) act on the host and play a pivotal role in maintaining health. Certain commensal bacteria have been shown to regulate the function of epithelial cells, immune cells in the intestinal mucosa, and other distant tissues. It is also becoming clear that the function of the metabolites produced by commensal bacteria is important as the mechanism of action. Furthermore, it has become clear that abnormalities in the balance of the microbiome are deeply related to the pathology of various diseases. In this symposium, we would like to discuss the microbiome's interaction with the host and its involvement with diseases.

Yasuo Mori (Kyoto University)
Yoshihiro Kubo (National Institute for Physiological Sciences)
Masateru Taniguchi (The University of Osaka)
Kazuya Tsurudome (Sophion Biosciemce)
Motohiro Nishida (Kyushu University)

Novel biological and technological insights of selectivity in sensing and ion permeability of channels

Michael Borg (Max Planck Institute for Biology)
Kensuke Kataoka (National Institute for Basic Biology)
Tetsuya Hisanaga (Nara Institute of Science and Technology)
Misato Ohtani (The University of Tokyo)
Yoko Ikeda (Okayama University)

In the process of evolution, extant organisms have evolved from a common ancestor and optimized growth and development strategies genetically and epi-genetically. Here we will focus on unique epigenomic regulation of reproduction, stem cell maintenance and morphogenesis in various species from aquatic organisms such as algae and Tetrahymena to land plants such as bryophytes, Arabidopsis and barley. By reviewing these findings along evolutionary pathways and comparing them with well-known animal systems, we will discuss how epigenomic regulatory systems have changed during the evolutionary process of adaptation from water to land, and the impact and importance of these changes.

Yuichiro Nakajima (The University of Tokyo)
Tetsuya Bando (Okayama University)
Ikuo Suzuki (The University of Tokyo)
Tamaki Yano (Tohoku University)
Shinji Yamaguchi (Teikyo University)

In many animals, tissue stem cells contribute to regeneration and homeostasis. Understanding the control mechanisms of these stem cells lays an important foundation for regenerative medicine. In addition to research using model animals, advances in analysis techniques for various animals have revealed new aspects of stem cell control mechanisms. In this symposium, we will introduce the latest research results using not only mice and fruit flies, but also promising model systems for regeneration and homeostasis study. We will discuss the benefits and potential to take advantage of these animals. Further, we might develop discussions oriented toward new treatments and regenerative medicine.

Hemmo Meyer (University of Duisburg-Essen)
Ichiro Nakagawa (Kyoto University)
Hayashi Yamamoto (Nippon Medical School)
Yoshihiko Kuchitsu (Tohoku University)
Shuhei Nakamura (Nara Medical University)
Akiko Kuma (The University of Osaka)

Autophagy is an evolutionally conserved lysosome dependent degradation system. There are several autophagy pathways, including macroautophagy and microautophagy and each pathway is accompanied by characteristic membrane dynamics. Recently findings such as phase separation of autophagic substrates and new functions of autophagy-related gene (ATG) add new perspective in the field. Nevertheless, there are a lot of remaining questions, such as the similarities/differences/crosstalk between macro- and microautophagy. In this symposium, we would like to introduce recent topics in macroautophagy and microautophagy research and discuss the mechanism and significance of autophagy.

Sumio Ohtsuki (Kumamoto University)
Masaki Matsumoto (Niigata University)
Jun Adachi (National Institute of Biomedical Innovation, Health and Nutrition)
Shinya Ohta (Hokkaido University)
Ayana Tomioka (Nakai) (Kyoto University)

Current advances in proteomics technologies have enabled detailed analysis of not only protein expression but also post-translational modifications such as phosphorylation and glycosylation. These innovations also allow for comprehensive studies of protein localization and interaction networks with unprecedented efficiency, significantly advancing our understanding of new biological systems and enabling the discovery of new therapeutic targets. This session will highlight how state-of-the-art proteomics technology unlocks insights into intracellular molecular mechanisms and disease pathogenesis, featuring case studies from the field.

Yosuke Katsuda (Kumamoto University)
Teigo Asai (Tohoku University)
Hiroki Akiba (Kyoto University)
Ryosuke Kojima (The Univerisity of Tokyo)
Fumika Yakushiji (Nagasaki University)

In drug discovery research, new strategies leveraging chemical biology approaches are attracting attention, and these are contributing to the creation of new therapeutic modalities that cannot be obtained through classical ligand screening or phenotypic screening. In this symposium, we invite 5 young researchers from a wide range of fields such as nucleic acid chemistry, natural product chemistry, antibody/protein engineering, exosome, and epigenetics to deepen our understanding of the diversifying chemical biology research in drug discovery and to discuss future directions of drug discovery research.

Tadashi Suzuki (RIKEN)
Kazuya Kabayama (The University of Osaka)
Jumpei Kondo (The University of Osaka)
Tohru Sugawara (Yokohama City University)
Suyong Re (National Institutes of Biomedical Innovation, Health and Nutrition)
Masahide Asano (Kyoto University)

The results of glycobiology have contributed to the development of new therapeutic modalities such as antibodies, enzyme replacement therapy for lysosomal diseases, antisense, and xenotransplantation. Furthermore, research on novel glycosylation drug targets and development of novel drug discovery technologies are expected to lead to more effective and safer modalities. This symposium will present the latest results of glycobiology research that will lead to tomorrow's drug modality innovations.

Ayaka Ito (Nagoya University )
Yuki Saito (Sapporo Medical University)
Jumpei Omi (The University of Tokyo)
Naoya Kataoka (Nagoya University)
Tomohisa Okamura (The University of Tokyo)

It has been revealed that chronic inflammation plays a role in the development of various diseases. Recently, the impact of multifaced stresses, including psychological stress, mechanical stress, metabolic imbalances, and cellular senescence, on immune responses has gained increasing attention. This symposium will explore the latest research on how these stress factors influence immune cell function and inflammatory responses. We aim to deepen discussions on the mechanisms underlying disease development and progression, as well as the potential for therapeutic strategies.

Shuichi Yanai (Tokyo Metropolitan Institute for Geriatrics and Gerontology)
Shinji Maegawa (Kyoto University)
Yoshitaka Kondo (Tokyo Metropolitan Institute for Geriatrics and Gerontology)
Yasunori Fujita (Tokyo Metropolitan Institute for Geriatrics and Gerontology)
Shuichi Machida (Juntendo University)
Ippei Shimizu (National Cerebral and Cardiovascular Center)

Extending a healthy lifespan is an urgent issue for a super-aging society. Aging is a major risk factor for many age-related diseases, and its regulation is key to the prevention and treatment of these diseases. To establish a methodology for regulating aging, it is essential to examine quantitative biomarkers and evaluation systems that reflect the degree of aging as well as intervention methods based on these biomarkers and systems. In this symposium, as "Research on aging regulation for healthy longevity", we will introduce the behavioral evaluation system of aging mice and epigenetic aging by DNA methylation, and then discuss the relationship between humoral factors and aging, the dietary macronutrient balance and health promotion, the anti-aging effect of exercise, and the development of treatments for age-related diseases focusing on molecules that promote aging.

Sihan Li (The University of Tokyo)
Caludio Jazeiro (Universitat Heidelberg)
Satoru Morimoto (Keio University)
Yuichiro Mishima (Kyoto Sangyo University)
Yasushi Yabuki (Kumamoto University)
Ryo Endo (RIKEN)

Recent studies have provided new insights into ribosome functions that go beyond the traditional view of ribosomes as mere translational machines. The ribosome-associated quality control (RQC) system identifies and resolves ribosome collisions, leading to the degradation of abnormal proteins and maintaining proteostasis. Ribosome collision triggers the integrated stress response and the ribotoxic stress response, highlighting the role of ribosomes as key sensors of stress that initiate corresponding responses. Additionally, ribosome dynamics regulate their stability through a branching ubiquitination mechanism. In this symposium, recent advances in understanding the molecular mechanisms of translation quality control, particularly focusing on its physiological functions in neurons will be presented.

Yuichiro Arima (Kumamoto University)
Akiko Koto (AIST)
Fumiaki Obata (RIKEN)
Atsushi Nakano (University of California)

The DOHaD theory, states that "an unfavorable environment during early development causes epigenetic changes in the child, which become a predisposition to disease, and the interaction with the postnatal environment leads to health and development of various non-communicable diseases (NCD)," has become widely recognized. It is thought that changes in the child's metabolism and endocrine system may largely contribute to NCD susceptibility. However, many details of environmental changes in metabolism and endocrine system and the mechanism of subsequent change in NCD susceptibility remain unclear. Therefore, in this symposium, we would like to discuss the biochemical mechanisms underlying the effects of the environment on metabolism, NCD susceptibility, and life span.

Fubito Nakatsu (Niigata University)
Takuro Tojima (RIKEN)
Miharu Maeda (Akita University)
Toshiki Itoh (Kobe University)
Yoko Shiba (Iwate University)
Takuma Kishimoto (Tohoku University)

Eukaryotic cells are compartmentalized by organelles, each carrying out highly specialized roles. Recent findings have revealed the existence of detailed functional domains, akin to “special districts," within the boundaries of these organelles. These "special districts" are not only linked to interactions between organelles but are also involved in forming unique lipid domains, coordinating with cytoskeletons, and interacting with cytoplasmic regions through liquid-liquid phase separation. While their functional roles as "special districts" are becoming increasingly evident, their full scope remains unclear.This symposium aims to bring together researchers who are actively advancing the fields of membrane trafficking and lipid biology across various methodologies and organisms. The goal is to discuss the future challenges in studying these organelle “special districts."

Naoki Watanabe (Kyoto University)
Masahiro Ueda (The University of Osaka)
Sei Yoshida (Nankai University)
Noriyasu Kamei (Kobe Gakuin University)
Ikuhiko Nakase (Osaka Metropolitan University)

The cell membrane, with its complex molecular mechanisms, has multifaceted receiving/transmitting functions ranging from acceptance/rejection responses to intracellular and extracellular stimuli, intercellular signal transduction, and functional responses. In this symposium, we will focus on macropinocytosis, a specialized endocytosis mechanism mediated by actin-reorganization and membrane ruffling, and discuss the understanding of macropinocytosis, including cancer development, and its chemical control and utilization from an interdisciplinary perspective including DDS. The importance of macropinocytosis in molecular based communication will be the focus of symposium by up-and-coming top-runner researchers, and discussions will be held on the possibilities for the fusion of technologies.

Hirokazu Yagi (Nagoya City University)
Mio Iwasaki (Kyoto University)
Kazutaka Ikeda (Kazusa DNA Research Institute)
Kazuyuki Yamagata (Chiba University)
Hiroaki Tateno (AIST)

The life system is formed through intricate multilayered interactions among genes, proteins, metabolites, and the epigenome. Understanding this complex and dynamic network requires “multidimensional omics" analysis, which integrates data from various biological layers. This symposium highlights technologies for integrating omics data, including genomics, transcriptomics, proteomics, and end-product omics such as glycomics, lipidomics, and metabolomics, with the goal of comprehensively elucidating life systems.Leading researchers will present state-of-the-art analytical methods and case studies, focusing on the discovery of unknown molecular networks and novel biological phenomena through multidimensional omics. Furthermore, the symposium will explore the practical applications of these findings in biochemistry, medicine, and biotechnology.

Takayuki Nojima (Kyushu University)
Takaaki Yasuhara (Kyoto University)
Koichi Ogami (Nagoya University)
Shunsuke Shimobayashi (Kyoto University)
Jafar Sharif (RIKEN)
Satoru Ide (Institute of Science Tokyo)

Gene regulation is fundamental to life activities, but our understanding of the basic mechanisms is still being updated. After biochemical characterization of regulators of gene regulation and transcription, the understanding of sequence-function relationships in gene regulation has been dramatically improved through genome-wide omics technologies using next-generation sequencers. Furthermore, in recent years, the importance of a spatial perspective has been emerging along with the relationships between gene regulation and phase separation, increasing a momentum for the development of new biochemical approaches. In this symposium, we will introduce the latest research on gene regulation and phase separation and their interdisciplinary research and discuss new research directions.

Mai Morita (Hoshi University)
Honoka Tokuhisa (Tottori University)
Akinori Endo (Tokyo Metropolitan Institute of Medical Science)
Tsukasa Okiyoneda (Kwansei Gakuin University)
Toshiaki Fukushima (Institute of Science Tokyo)
Yuri Shibata (The University of Tokyo)
Kenta Hagiuda (Institute of Science Tokyo)
Hirotaka Takahashi (Ehime University)

Ubiquitination is a crucial post-translational modification in all eukaryotic cells, regulating various cellular functions, including endocytosis and signal transduction, as well as proteasome degradation. In cells, ubiquitination is balanced between the addition of ubiquitin to target proteins by ubiquitin ligase (E3) and their removal by deubiquitinating enzymes (DUBs). In this symposium, young researchers will introduce recent advances in the diversity and biology of protein ubiquitination mediated by the “DUBs", from the viewpoint of molecular basis, physiological functions, and disease relevance.

Shingo Kasamatsu (Osaka Metropolitan University)
Masatomo Watanabe (Fukuyama University)
Yoshifumi Yamaguchi (Hokkaido University)
Yuko Okamatsu (Hokkaido University)
Akira Murakami (University of Shizuoka)

Mammalian hibernation is characterized with low body temperature and low metabolism, which is achieved by dramatic metabolic suppression Mammalian hibernation is characterized with low body temperature and low metabolism, which is achieved by dramatic metabolic suppression and deviation from homeothermy. Hibernation has long captured people's interest, and its research history spans over a century. However, its regulatory mechanisms remain a mystery. Recent technological development has made it possible to study mammalian hibernators itself, which were previously difficult to analyze in detail. This symposium will introduce cutting-edge researches that seek to uncover the mechanisms of mammalian hibernation.

Toshihisa Ohtsuka (University of Yamanashi)
Eiichiro Mori (Nara Medical University)
Masaya Imoto (Juntendo University)
Ruby Chen (Academia Sinica)
Yuka Mitsuhashi Koike (Niigata University)

Liquid-liquid phase separation (LLPS) plays a key role in regulating synaptic structure, maintaining protein homeostasis, and mediating the transition of proteins between functional and pathological states. Dysregulation of LLPS underlies key mechanisms of proteinopathies and misfolded protein-driven neurodegenerative diseases. This symposium will explore LLPS in presynaptic active zone assembly, its influence on protein-protein interactions, and how liquid droplets drive pathogenic aggregation, with a focus on proteins such as α-synuclein and TDP-43. By integrating perspectives from synaptic biology, protein biophysics, and neurodegeneration, the symposium aims to deepen our understanding of LLPS in cellular function and disease progression.

Kouichi Nishiyama (Miyazaki University)
Shota Shimizu (Keio University)
Somin Lee (Harvard Medical School)
Shin Fujimaki (Kumamoto Univeristy)
Shigetomo Fukuhara (Nippon Medical School)
Takashi Minami (Kumamoto University)

Mammals grow based on precise angiogenesis during embryonic development and then acquire a fine-tuned vascular system tailored to each organ to maintain homeostasis. Such vascular formation begins with branching and the elongation of pre-existing vessels, a process governed by the microscopic dynamic control of the ‘tip and stalk' cells. In contrast, from a macroscopic perspective, the microenvironment regulates the vascular diversity that supports distinct functions in each organ. In this symposium, we would like to discuss fine-tuned angiogenesis, the genomic/epigenomic regulation of tip/stalk cells, and observing vascular diversity in the organ. Moreover, from a biochemical view, we want to discuss how the breakdown of these regulatory systems correlates with vascular diseases or aging.

Imari Mimura (The University of Tokyo)
Kento Kitada (Kagawa University)
Airi Jo (Juntendo University)
Yuya Yoshida (Kyushu University)
Jun Nakamura (University of Pennsylvania)

Chronic kidney disease (CKD), which affects more than 1 in 8 Japanese people, continues to increase in prevalence and can be considered a new national disease. The kidney is primarily known for its roles in blood pressure regulation and waste removal. However, recent research has revealed that the kidney has relationships with various organs such as the brain, heart, liver, and bone marrow. Because the kidney is composed of a complex network of various types of cells, there have been few groundbreaking treatments to halt its progression. Nevertheless, uncovering the mechanisms of its interactions with multiple organs could open the door to new therapeutic targets. This symposium highlights cutting-edge findings from young researchers in Japan and abroad, aiming to inspire interest in nephrology and encourage collaborative research within the Japanese Biochemical Society.

Satoshi Watanabe (Kyushu University)
Umeharu Ohto (University of Tokyo)
Masahiro Fukuda (University of Tokyo)
Reiya Taniguchi (RIKEN)
Hironori Takeda (Kobe University)

Structural biology seeks to understand molecular mechanisms by determining protein 3D structures. Traditionally, techniques like X-ray crystallography, cryo-electron microscopy (cryo-EM), and NMR spectroscopy have provided atomic-level insights into protein function and interactions. However, recent advances extend beyond individual structures to larger biological systems, exploring supramolecular complexes, organelles, and cells.This session brings together researchers who integrate structural analysis with higher-order biological studies, offering a macroscopic perspective on life's fundamental processes. Leading scientists will present their latest findings and discuss future directions in this evolving field.

Noritaka Hashii (National Institute of Health Sciences)
Satoru Nagatoishi (The University of Tokyo)
Koichi Kato (National Institutes of Natural Sciences)
Masato Kiyoshi (National Institute of Health Sciences)
Susumu Uchiyama (The University of Osaka)

In recent years, various technological advances such as antibody engineering and AI-based prediction of protein higher-order structure have promoted medical innovation. For new molecules generated from laboratory work to be developed as drugs, the molecular properties should be analyzed in detail and they should be stably supplied as drugs. In this symposium, we will introduce the latest trends in research on the development of analytical methods using multi-attribute methods using LC/MS, unlabeled NMR, and cryo-electron microscopy as next-generation antibody analysis techniques as well as rapid optimization of drug formulations that contribute to development of innovative medicine. We will also discuss the role of evaluation technology research that leads to state-of-the-art medical innovation.

Noriko Yamano (The University of Osaka)
Ryutaro Asano (Tokyo University)
Masayuki Oda (Kyoto Prefectural University)
Kento Tanaka (Daiichi Sankyo Co., Ltd.)
Shino Manabe (Hoshi University)
Takashi Matsumoto (Rigaku Corporation)

This symposium aims to widely share the latest research trends on antibody structure and function and provide a platform for discussions on future research developments. In recent years, antibodies with novel functionalities, such as bispecific antibodies, clearance antibodies, and antibody-drug conjugates (ADCs), have gained significant attention, advancing applications in drug discovery and therapeutic fields. Additionally, there has been rapid progress in the development of efficient antibody production technologies and innovative techniques that enable structural analysis in solution. This symposium will invite leading researchers in these fields to engage in discussions from a broad perspective, covering both fundamental research and applications. Through this conference, we aim to explore further advancements in antibody research and uncover new prospects for the field.

Masahito Ikawa (The University of Osaka)
Akira Shinohara (The University of Osaka)
Tsuyoshi Terakawa (Kyoto University)
Florence Tama (Nagoya University / RIKEN)
Yongchan Lee (Yokohama City University)

In addition to advances in experimental techniques for biomolecular structure analysis, the emergence of AlphaFold has transformed the landscape of modern biology, bringing about an era flooded with diverse structural information. In this context, we invite researchers employing innovative approaches to address key biological questions and explore the future of biological research.

Tetsuya Miyamoto (Kitasato University)
Ryushi Kawakami (Tokushima University)
Naoko Yoshikawa (Shizuoka Institute of Science and Technology)
Robin Roychaudhuri (University of Maryland School of Medicine)
Tomohisa Sujino (Keio University)
Jumpei Sasabe (Keio University)

Most amino acids exist as both D- and L-enantiomers, with organisms primarily utilizing L-amino acids, a phenomenon known as homochirality. However, advances in analytical technologies have revealed that homochirality in biological systems is not as rigid as previously thought. Specifically, biosystems that utilize D-enantiomers have been identified across all domains of life–bacteria, archaea, and eukaryotes. In recent years, D-amino acids with crucial physiological functions, along with unique D-amino acid-metabolizing enzymes, have been discovered. This symposium will highlight the latest findings on D-amino acid-metabolizing enzymes and their physiological functions across these three domains. We will also explore the emerging roles of D-amino acids in mammals, including their potential involvement in various diseases.

Eun-Woo Lee (KRIBB)
Cheol-Sang Hwang (Korea University)
Ken-ichi Yamada (Kyushu University)
Junya Ito (Tohoku University)

Ferroptosis, a newly identified form of iron-dependent cell death, has garnered significant attention due to its potential to advance novel therapeutic approaches for a wide range of diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. In this second joint symposium with the Korean Society for Biochemistry and Molecular Biology (KSBMB), we will focus on the molecular mechanisms of ferroptosis, its impact on the intracellular environment, and its potential therapeutic applications. Promising next-generation researchers leading cutting-edge ferroptosis research will be invited to present their findings. The symposium aims to facilitate interdisciplinary collaboration through discussions spanning basic research to clinical applications, offering a platform for sharing the latest insights and envisioning new avenues for medical innovation.

Yuuki Imai (Ehime University)
Akira Nozawa (Ehime University)
Hiroyuki Yamakoshi (Tohoku University)
Tetsuya Takano (Kyushu University)
Tomonori Tamura (Kyoto University)
Shreyas Sridhar (The University of Osaka)

Many proteins in living organisms function by interacting with other proteins to form complexes. It is believed that higher organisms regulate the formation of these complexes to control protein function, which enables them to carry out sophisticated biological activities. The BioID method has been developed to investigate these interactions. This method involves fusing a biotinylation enzyme to a target protein, which biotinylates proximal proteins, allowing for their identification. In this symposium, we will introduce the current state of technologies for searching and analyzing interacting proteins within organisms, with a focus on exploring the regulatory mechanisms of complex biological phenomena using proximity biotinylation methods. We will also discuss the future potential of the BioID technology.

Takuma Shiraki (Kindai University)
Tomoya Kitajima (RIKEN)
Josephine Galipon (Yamagata University)
Tsuyoshi Ikura (Kyoto University)

Synergetics refers to whole-system behaviors that cannot be predicted by the behavior of individual components in isolation. In the era of omics analysis, where multiple elements can be analyzed comprehensively, we sometimes encounter biological phenomena whose mechanisms cannot be understood merely by reducing them to their individual components. By overcoming this challenge, we can surpass current knowledge and uncover new biological concepts. In this symposium, we would like to discuss the future of biochemistry by inviting researchers who are trying to open up such unknown areas by combining traditional biochemical approach with new technologies such as mathematics, synthetic biology, and AI to address unanswered questions, identify potential solutions, and tackle future challenges.

Pradeep Reddy (Altos Labs)
Shogo Sato (Texas A&M University)
Keishi Kishimoto (RIKEN)
Yoshikazu Johmura (Kanazawa University)
Tomoaki Hishida (Wakayama Medical University)

Since the establishment of induced pluripotent stem cells in 2006, research on cell reprogramming has rapidly advanced. In parallel with these advancements, reprogramming-based approaches for anti-aging and lifespan extension have also been developed. Not only aging, but also the reversal of the biological processes traditionally considered "irreversible" has become an active research area both domestically and internationally. In light of these global trends, this symposium will invite leading researchers from Japan and abroad to present the latest research findings in various fields, including aging, tissue regeneration, circadian rhythms, and organoids. Additionally, we will discuss the challenges and future prospects of reversing biological phenomena, with the goal of exploring new approaches to irreversible biological phenomena, including aging.

Sho Aki (The University of Tokyo)
Isshin Shiiba (Gakushuin University)
Ayumu Sugiura (Juntendo University)
Shun Nagashima (Tokyo University of Pharmacy and Life Sciences)
Yuhei Araiso (Kanazawa University)
Noriko Nagata (Japan Women's University)

Organelles, characteristic of eukaryotic cells, are not just "containers" for substances and enzymes, but dynamically change their morphology and localization to regulate cellular functions. Advances in imaging, such as super-resolution microscopy, reveal that organelles (dots) connect via contact sites to form organelle networks (lines). These networks regulate metabolism, signaling, and morphology to maintain cellular homeostasis. They are universal, yet diverse across species, and play key roles in eukaryotic evolution and function. The symposium will present cutting-edge research on organelle networks using advanced imaging and analysis. It will also stimulate collaboration and inspire new areas of research.

Jose Angeli (University of Wuerzburg)
Yusuke Hirata (Tohoku University)
Masamitsu Sone (Hokkaido University)
Yoshiro Saito (Tohoku University)

More than 10 years have passed since the discovery of "ferroptosis," a cell death involving iron-dependent lipid peroxidation. Ferroptosis is involved in disorders such as cerebral ischemia-reperfusion injury, neurodegenerative diseases, and liver and kidney diseases, and acts as a target for toxic substances, growing into a research field with top journals. Ferroptosis research has also been developed as a new modality for anticancer drugs by controlling its sensitivity. In this symposium, cutting-edge researchers in ferroptosis will introduce their recent research results and discuss their physiological and pathological significance. We hope this symposium will be an opportunity to understand the essence of ferroptosis and deepen and develop it into a new research field.

Eiji Inoue (Kyushin Pharmaceuticals Ltd)
Norihiro Okada (Kitasato University)
Hideko Sone (Yokoha University of Phrmacy)
Naoki Itou (Kitasato University)

Traditional herb medicine has been selected and established from long historical works. In fact, the effectiveness of several traditional herb medicines has been reported even during corona pandemic. In this symposium, we gathered scientists who studied the mechanism of traditional herb medicine using molecular biology and biochemistry. They will talk and discuss new concepts how traditional herb medicine works for heat-shock, intron-retention, cancer, and depression.

Masanori Hatakeyama (Institute of Microbial Chemistry / Hokkaido University)
Midori Shimada (Nagoya University)
Kazuo Asanuma (Kyushu University)
Ryo Fujita (University of Tsukuba)
Satomi Komori (Kobe University)
Kazuyasu Sakaguchi (Hokkaido University)
Rui Kamada (Hokkaido University)
Nobuhiro Tanuma (Miyagi Cancer Center Research Institute)

Protein phosphorylation, a critical process in various biological phenomena, is tightly regulated by protein kinases and phosphatases. Recent studies have shown that dysfunction of protein phosphatase regulation contributes to diseases such as cancer, immune disorders, and muscular diseases, drawing attention to their roles in disease mechanisms and drug discovery.This symposium brings together researchers from fields like science, medicine, and pharmacy, focusing on young and mid-career scientists leading this area. It will feature new insights into protein phosphatases' functions in disease and homeostatic signaling and innovations in research methods. Through discussions, the symposium aims to deepen understanding and inspire new directions in biochemical research.

Yasuyuki Matsumoto (U.S. Food and Drug Administration)
Yuhsuke Ohmi (Chubu University)
Kazuaki Ohtsubo (Kumamoto University)

Mammalian cells express glycans, and their glycan expression pattern is often altered in cancer. Glycans that are cancer-specific and/or involved in malignancy are so called cancer-associated glycans(CAGs). Understanding CAGs is considered difficult because glycans themselves are complicated molecules. In this symposium, we will try to dispel the negative impression of CAGs by providing an easy introduction to the latest knowledge about them. Genomics is now the most important field of cancer research, while glycosylation is not directly imprinted in genomes. Glycans are potential next therapeutic targets beyond genomics. Collaboration between different research fields is needed to achieve cancer outcomes and we hope that this symposium will stimulate it.

Toshiyuki Sakaki (Toyama Prefectural University)
Takahiro Sawada (Iryo Sosei University)
Kuniko Horie (Saitama Medical University)
Umeda Kaori (Nihon University)
Akihiko Yoshimura (Tokyo University of Science)

Nuclear receptors (NRs) comprise a superfamily of transcription factors that respond to steroid hormones and other lipophilic ligands, including orphan receptors with unknown or ligand-independent function. They govern essential physiological processes in higher organisms, and recent findings underscore their pivotal roles in disease initiation and progression. Their epigenetic regulatory activities, which affect chromatin organization, are closely linked to cancer development and exacerbation. Moreover, NRs serve as potential biomarkers and drug targets, offering significant industrial applications. This symposium highlights cutting-edge research by Japanese groups exploring diverse NRs in various biological contexts, fostering collaboration and future breakthroughs.