Hideo Shindo (National Center for Global Health and Medicine)
Junko Sasaki (Medical Research Institute, TMDU)
Yukihiko Sugimoto (Kumamoto University Graduate School of Pharmaceutical Sciences)
Hyeon-Cheol Lee-Okada (Juntendo University Graduate School of Medicine)
Yoshitaka Taketomi (Graduate School of Medicine, The University of Tokyo)

Mass spectrometry is now widely used in lipid research, enabling the analysis of a wide variety of lipids. Through the analysis of pathological models in mice genetically engineered for lipid-related molecules, and lipid analysis of a large number of human specimens, the pathogenic mechanisms of diseases caused by lipid abnormalities are becoming clearer. In this symposium, we would like to discuss the latest findings on the relationship between lipids and diseases as revealed by studies on membrane lipids and bioactive lipids in humans and mice.

Hideki Taguchi (Cell Biology Center, Tokyo Institute of Technology)
Shunsuke Tagami (RIKEN Center for Biosystems Dynamics Research)
Motomasa Tanaka (RIKEN Center for Brain Science)
Kotaro Tsuboyama (The University of Tokyo)
Patricia Clark (University of Notre Dame)

One of the fundamental issues in protein science is the problem of protein folding, i.e., how proteins acquire their three-dimensional structures. The concept of folding has continued to expand to include chaperones, intrinsically disordered proteins/regions, and amyloid/prions. In recent years, new issues have emerged, such as cotranslational folding and folding of de novo design proteins. Folding studies also have a significant impact on the association with human diseases, as exemplified by amyloidosis. In this symposium, we will discuss the next generation of folding research by those who have been conducting research that is beyond the scope of conventional folding concept.

Kazuhiro Iwai (Department of Molecular and Cellular Physiology Graduate School of Medicine, Kyoto University)
David Komander (Walter and Eliza Hall Institute of Medical Research)
Yasushi Saeki (Division of Protein Metabolism, The Institute of Medical Science, The University of Tokyo)
Yukiko Yoshida (Tokyo Metropolitan Institute of Medical Science)
Jun-ichi Sakamaki (Department of Physiology, Juntendo University Graduate School of Medicine)
Fumiaki Ohtake (Institute for Advanced Life Sciences, Hoshi University)

Ubiquitin modifies substrates in different ways to govern varieties of cellular pathways. Recent studies revealed ubiquitin chains of complex architectures, ubiquitin linkages via non-lysine residues, and ubiquitylation of non-protein substrates such as lipids, further expanding the world of the ubiquitin code. On the other hand, the detailed analyses on how the ubiquitin code is encoded and decoded in the regulation of proteasomal degradation and immune signaling are undergoing using proteomics strategies. In this symposium, we will discuss these leading-edge research topics together with Dr. David Komander, a leading scientist in the ubiquitin research field.

Suguru Hatazawa (Institute for Quantitative Biosciences, The University of Tokyo)
Kenichi Umeda (Kanazawa University)
Akihisa Osakabe (Department of Biological Sciences, The University of Tokyo)
Tsuyoshi Terakawa (Graduate School of Science, Kyoto University)
Kayo Hibino (National Institute of Genetics)
Ayako Furukawa (Kyoto University)
Kyohei Arita (Yokohama City University)

Our genomic DNA including genetic information is stored in chromatin. Epigenetics (DNA methylation, histone modifications), chromatin remodeling factors, and SMC proteins regulate chromatin structural dynamics, and gene expression is regulated at the appropriate timing and space. The elucidation of chromatin structural dynamics has been dramatically increased owing to some technological innovations. In this symposium, we aim to understand the molecular basis of chromatin conformational dynamics by cryo-EM single particle analysis and tomography, NMR, super-resolution single molecule analysis, high-speed atomic force microscopy, and MD simulations.

Yoriko Atomi (Teikyo University, Advanced Comprehensive ResearchOrganization)
Yasuhiro Sawada (National Rehabilitation Center for Persons withDisabilities)
Laurent Blanchoin (CNRS/CEA/DRV IRTSV)
Daisuke Inoue (Faculty of Design, Kyushu University)
Motoshi Kaya (Graduate School of Science, University of Tokyo)
Eri Fujita (Tokyo Woman's Christian University)

Humans bodies are designed to move. Movement is a mechanical stress that simultaneously activates the tissues, cells, and molecules that make up the body through abundant biochemical reactions. The interaction of the three-dimensional structure of proteins creates biological functions, which work in the cell where they are extremely soft and unstable and maintain structural suppleness and redundancy, even striated skeletal muscle. This symposium will connect the hierarchy from the basic systems that transmit the forces of the living system and propose strategies to prevent flail and sarcopenia.

Zhenyu Yue (Icahn School of Medicine at Mount Sinai)
Miyuki Sato (Gunma University)
Masaaki Komatsu (Juntendo University)
Akiko Kuma (Osaka University)
Tomoya Eguchi (The University of Tokyo)

Autophagy is an intracellular degradation system that is conserved among many eukaryotes. During autophagy, a portion of the cytoplasm is engulfed by autophagosomes and then transported to lysosomes for degradation. Significant progress has been made in elucidating the mechanism of selective autophagy and understanding the physiological and pathological functions of autophagy since the pioneering studies conducted in yeast by Dr. Ohsumi. This symposium will address recent topics on the mechanism and significance of autophagy from a variety of perspectives.

Richard Youle (National Institutes of Health)
Takahiro Yasumi (Kyoto University Graduate School of Medicine)
Hyota Takamatsu (National Hospital Organization Osaka Minami Medical Center)
Tomohiko Taguchi (Graduate School of Life Sciences, Tohoku University)
Kensuke Miyake (The Institute of Medical Science, The University of Tokyo)

Eukaryotic cells have a number of intracellular organelles with distinct functions. Interestingly enough, these organelles never function alone; they cooperatively regulate cellular homeostasis, proliferation, and differentiation, through a continuous exchange of soluble and membrane-bound molecules via membrane trafficking and/or membrane contact transfer. In this symposium, five experts in organelle physiology and pathology (the Golgi, endosomes, lysosomes, mitochondria) will present their recent data and discuss how the impaired function of or cooperation between these organelles leads to human diseases.

Jennifer Kohler (University of Texas Southwestern Medical Center)
Hiroaki Tateno (AIST)
Shintaro Iwasaki (RIKEN Cluster for Pioneering Research)
Taiki Saito (Nagoya City University)
Morihisa Fujita (iGCORE, Gifu University)

Glycans are often regarded as the "third biological chain of life" after nucleic acids (DNA/RNA) and proteins, and the involvement of glycans in various cellular processes has been well documented. However, the misconception that "glycoscience" is a special field of study by researchers with special skills persists, hindering the comprehensive understanding of glycans. On the other hand, recent technological innovations have been remarkable, making it possible to characterize phenomena that are otherwise difficult to analyze with conventional methodology. In this symposium, we invite experts of innovative technologies, which help us to understand the glycoscience.

Takuya Matsuo (Kitasato Univ.)
Masao Doi (Kyoto Univ.)
Shuji Akiyama (Institute for Molecular Science)
Kazuhiro Yagita (Kyoto Prefectural University of Medicine)
Norihito Nakamichi (Nagoya University)
Hikari Yoshitane (Tokyo Metropolitan Institute of Medical Science)

This symposium is co-organized with Transformative Research Areas (A) "Chronoproteinology". The biological rhythms and timers count “time" on multiple scales from seconds to years, such as heartbeats, segmentation clock, circadian rhythms, seasonal responses, and bamboo flowering. We will introduce phenomena and the mechanisms of these biological rhythms and timers. As the molecular mechanisms responsible for counting biological time scales, we will focus on protein-protein interactions, post-translational modifications, conformational changes, and translational control.

Michiko Ito (Tokyo Medical University)
Kiyoshi Hirahara (Department of Immunology, Graduate School of Medicine, Chiba University)
Motohiro Nishida (Department of Physiology, Graduate school of pharmacology, Kyushu University)
Yoshikazu Johmura (Division of Cancer and Senescence Biology, Cancer research institute, Kanazawa University)
Norihiko Takeda (Department of Cardiovascular Medicine, School of Medicine, Tokyo University)

Cellular metabolism is the process by which energy is extracted from nutrients ingested by cells and supply of intermediate metabolites for the synthesis of bioconstituent molecules. Cellular metabolism is regulated in concert with systemic energy metabolism. Recently, much attention has been paid to the fact that cellular functions are regulated in close coordination with cellular metabolism to control tissue homeostasis and various types of diseases. In this symposium, we would like to present and discuss the latest findings on the pathophysiological regulation of inflammation, chronic allergic diseases, cancer and various age-related diseases by cellular and energy metabolism.

Injune Kim (KAIST)
Keisuke Yanagida (National Center for Global Health and Medicine)
Kyoko Hida (Hokkaido University)
Ayano Chiba (Yamagata University)
Shigetomo Fukuhara (Nippon Medical School)
Takashi Minami (Kumamoto University)

We obtain a closed vascular circuit system, which performs specific functions in each organ to maintain homeostasis. However, as Dr. Osler's aphorism states, aging and functional decline start at the blood vessels, which eventually causes death due to the blood flow being interrupted, driving cardiopulmonary arrest. These life events, birth, aging, disease, and death, are tightly correlated to vasculogenesis, angiogenesis, vascular inflammation, vascular aging, and thrombosis. In this symposium, we would like to present the latest findings in regulating vascular dynamics based on the perspectives of genetics, developmental cell biology, and pathophysiology and engage in a broad discussion.

Yoshihito Nihei (Department of Nephrology, Juntendo University Faculty of Medicine)
Kumiko Torisu (Department of Integrated Therapy for Chronic Kidney Disease, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan)
Yuji Kamijo (Shinshu University Hospital)
Takefumi Mori (Division of Nephrology and Endocrinology, Tohoku Medical and Pharmaceutical University Faculty of Medicine)
Shuichiro Yamanaka (Division of Nephrology and Hypertension, The Jikei University School of Medicine)

The kidneys have a central role in the regulation of water-electrolyte balance, blood pressure, erythrocyte metabolism, and bone metabolism for the maintenance of systemic homeostasis. Understanding the complex inter-organ crosstalk is paramount to discover novel therapeutic strategies for kidney diseases. This symposium will focus on systemic biochemical abnormalities involved in disruption of kidney function. This symposium is conducted to introduce the latest research progress on kidney diseases to the member of the Japanese Biochemical Society. The Japanese Society of Nephrology encourage to expand renal research consortiums.

Keisuke Yaku (Faculty of Medicine, University of Toyama)
Nobuhiro Tanuma (Miyagi Cancer Center Miyagi Cancer Center Miyagi Cancer Center)
Masahiro Aoki (Aichi Cancer Center)
Shinpei Kawaoka (Institute of Department, Aging and Cancer, Tohoku University)

Nicotinamide adenine dinucleotide (NAD) is an essential cofactor that mediates various redox reactions through the transfer of electrons. Additionally, NAD+ serves as a pivotal substrate for NAD+-consuming enzymes, thereby intricately regulating diverse biological processes. Recent investigations have illuminated the involvement of NAD+ metabolism in in cancers and various diseases characterized by metabolic abnormalities has spurred heightened interest. This symposium aims to present cutting-edge insights into the relationship between NAD+ and diseases, exploring various perspectives ranging from pathological mechanisms to diagnostic and therapeutic applications.

Sae Tanaka (Exploratory Research Center on Life and Living Systems)
Christoph Gerle (Advanced Photon Technology Division, RIKEN SPring-8 Center (RSC))
Shigehiro Enkai (Teikyo University Hospital)
Fuyuki Tokumasu (Graduate School of Health Sciences, Gunma University)
Kunio Nakatsuka (Graduate School of Science, Nagoya City University)
Gregory Cook (School of Biomedical Sciences, Faculty of Health, Queensland University of Technology (QUT).)

The diversity of central metabolism is crucial for understanding the adaptability and evolutionary strategies employed by different organisms. It encompasses the interconnected pathways involved in the conversion of nutrients into energy and building blocks for cell maintenance and growth. Such diversity is exploited by most of pathogenic and non-pathogenic organisms to adapt and to survive the environmental challenges throughout the life cycle. In this symposium, we will highlight groundbreaking studies by world leading scientists in the field of metabolism from host and microorganisms.

Hiroshi Nishimasu (The University of Tokyo)
Hideaki Kato (The University of Tokyo)
Takayoshi Awakawa (RIKEN)
Naoya Kobayashi (Nara Institute of Science and Technology)

Enzymes in nature boast an astonishing diversity and support life in various environments. Currently, the number of enzymes with EC numbers exceeds 8000 and is increasing at a rate of about 150/year, but most of them are variations of known enzymes, and few enzymes can be called truly new. One of the most exciting parts of biochemistry is finding new enzymes. This symposium will introduce the state-of-the-art of amazing enzymes, including recently developed protein design methods.

Shinobu Kitazume (Fukushima Medical University)
Yuji Kondo (Nagoya University)
Motoyuki Itoh (Chiba University)
koji ikeda (Kyoto Prefectural University of Medicine)
Hideyuki Takeuchi (University of Shizuoka)
Yusuke Ono (Kumamoto University)

Glycans play a crucial role in intercellular communication by serving as key constituents of the extracellular environment, providing a platform for protein interactions. The NOTCH receptor, a glycoprotein governing Notch signaling, directly involves glycans in qualitative signal changes. Precise control of Notch signaling is vital for maintaining organismal homeostasis, and its dysregulation is reported to contribute to age-related decline in physiological functions. This symposium aims to discuss the pathophysiology resulting from abnormalities in the intercellular environment, with a specific focus on Notch signaling in blood vessels and skeletal muscles.

Yasuhiko Kizuka (Gifu University)
Toshihiko Katoh (Kyoto University)
Masamichi Nagae (Osaka University)
Ryoichi Arai (Shinshu University)
Kazuhiko Yamasaki (National Institute of Advanced Industrial Science and Technology (AIST))

Glycans are biomolecules with high abundance and structural diversity, which are located at any cell forefront and play critical roles in numerous processes, including cell adhesion, neural network formation, self-nonself recognition, symbiosis, and infection. For glycan functions and their regulation, molecules or modules for decoding glyco-code by recognizing specific glycans are required. Recently, a new lectin module was unexpectedly found, and creation of neo-lectins has progressed based on structural biology and protein engineering. In this symposium, researchers working on the functions, modifications, and creation of glyco-code decoders will give their recent findings.

Ayako Nakamura-Ishizu (Tokyo Women's Medical University)
Mashito Sakai (Nippon Medical School)
Hayashi Yamamoto (Institute for Advanced Medical Sciences, Nippon Medical School)
Izumi Yanatori (Kyoto University Graduate School of Medicine)
Toshiro Moroishi (Faculty of Life Sciences, Kumamoto University)

Iron functions as a cofactor, regulating diverse biochemical reactions in cells. Recent research uncovers intercellular iron transfer through extracellular vesicles or the extracellular matrix, as well as the cell-to-cell propagation of ferroptosis. The understanding of the role of iron in life science research has expanded from the molecular level to individual cell functions, intercellular communications, and the maintenance of tissue homeostasis. This symposium aims to introduce the latest research concerning molecular and cellular networks strictly controlled by iron and discuss its physiological and pathological significance.

Yosuke Funato (Graduate School of Engineering, Kyoto University)
Seiryo Ogata (Tohoku University Graduate School of Medicine)
Hiroaki Fujita (Graduate School of Medicine, Kyoto University)
Hirotaka Imai (Kitasato University School of Pharmacy)
Yasumitsu Ogura (Graduate School of Pharmaceutical Sciences, Chiba University)

Group 16 elements (oxygen, sulfur, selenium, tellurium, polonium, livermorium) exhibit unique properties rich in electron transfer abilities. Sulfur, selenium, and tellurium form compounds with metals, serving as principal components in various ores, hence collectively termed ore-former "chalcogen". Biological studies on chalcogens have traditionally focused on individual elements, but recent findings have unveiled a novel energy metabolism regulated by crosstalk among chalcogens, particularly in the cooperative action of supersulfide and Selenoproteins. This symposium introduces latest research outcomes on the biological roles of chalcogens, fostering discussions on chalcogen biology.

Takeshi Maruyama (Department of Life Science, Tokyo University of Pharmacy and Life Sciences)
Keigo Ogawa (Graduate School of Biostudies, Kyoto University)
Motoyuki Ogawa (Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo)
Toru Hiratsuka (Oncogenesis and Growth Regulation, Osaka International Cancer Institute)
Seitaro Nomura (Department of Frontier Cardiovascular Science, Graduate School of Medicine, The University of Tokyo)
Tatsushi Igaki (Laboratory of Genetics, Kyoto University Graduate School of Biostudies)

The phenomenon of cell competition, discovered half a century ago in fruit flies and later extensively studied in fish and mammals, has accumulated a wealth of knowledge on the principles and mechanisms triggering this phenomenon. While cell competition serves as a system for individual optimization by maintaining more adaptive cells, its failure can contribute to the onset of diseases. In this symposium, we aim to present new findings arising from interactions among cells of the same type and the latest insights into the recognition and elimination mechanisms targeting aberrant cells. Additionally, we seek to engage in discussions on the artificial control of these processes.

Hiromi Yamazaki (Department of Hematology-Oncology, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe)
Hiroshi Kobayashi (Tohoku University Graduate School of Medicine)
Ichiro Manabe (Chiba University)
Soichi Sano (National Cerebral and Cardiovascular Center)
Tomoya Muto (Division of Cancer RNA Research, National Cancer Center Research Institute)
Tomomasa Yokomizo (Department of Microscopic and Developmental Anatomy, Tokyo Women's Medical University)

The hematopoietic system has the most defined differentiation hierarchy of all human somatic stem cell systems. Numerous studies have been conducted on the internal regulatory mechanisms of the hematopoietic stem cells (HSCs) themselves, which are responsible for self-renewal and differentiation, and on the external regulatory mechanisms mediated by the bone marrow niches. However, the mechanisms during embryonic hematopoiesis, adult hematopoietic failure and the systemic impact of clonal HSCs remain unexplored. In this symposium, we will discuss the mechanisms that define steady state, aging, and tumors in HSCs and provide a clue to homeostasis in the body from a biochemical point of view.

Etsuo Susaki (Juntendo University Graduate School of Medicine)
Kosuke Tomimatsu (Division of Transcriptomics, Medical Research Center for High Depth Omics, Medical Institute of Bioregulation, Kyushu University)
Junichi Kikuta (Department of Immunology and Cell Biology, Graduate School of Medicine, Osaka University)
Hideaki Yoshimura (Analytical Chemistry, Department of Chemistry, School of Science, The University of Tokyo)
Fumi Kubo (Lab for Sensorimotor Integration, RIKEN Center for Brain Science)

The symposium focuses on the multidimensional omics approach for understanding living organisms' intricate systems. It emphasizes research on capturing and analyzing molecular, spatial, and temporal dimensions using technologies like spatial omics, cell omics, and bioimaging. The speakers will discuss their innovations and practical implementations in the life sciences. The symposium also aims to foster discourse on strategies for achieving the ultimate omics, encompassing all dimensions of biological information.

Yohei Mikami (Keio University)
Miwako Kakiuchi (The University of Tokyo)
Yasuhiro Murakawa (Kyoto University)
Ying Gu (BGI-Research)
Keishi Fujio (The University of Tokyo)

Tissue adaptive repair mechanisms are a universal phenomenon observed in the development of various diseases. However, with recent advances in single cell genomics analysis technology, adaptive repair mechanisms specific to diseases and tissues have been revealed one after another. At this symposium, we will have lectures from cutting-edge researchers who are trying to elucidate the entire adaptive repair mechanism by deciphering genetic information imprinted in tissues with high resolution at the cellular and spatial levels. We further would like to discuss the future prospects of future life science research together with all the participants.

Takahiro Nemoto (Department of Physiology, Nippon Medical School)
Tomoko Kawai (Department of Maternal-Fetal Biology, Research Institute, National Center for Child Health and Development)
Masatoshi Ooga ( Azabu University)
Yuta Takahashi (Altos Labs)
Joji Kusuyama (Tokyo Medical and Dental University (TMDU))

Many adult diseases result from the complex interplay of genetic and environmental factors, rather than from a single gene alone. Particularly, the concept that stress during peri-natal development affects the formation of disease in adulthood, is known as the Developmental Origins of Health and Diseases (DOHaD) hypothesis. While multiple epidemiological studies have revealed several lifestyle-related diseases to be associated with DOHaD, understanding of the underlying mechanisms remains inadequate. This symposium aims to bring together cutting-edge researchers who are advancing the understanding of the impact of environmental factors on intergenerational transmission.

Hironori Kawakami (Sanyo-Onoda City University)
Hisao Masai (Tokyo Metropolitan Institute of Medical Science)
Shou Waga (Japan Women's University)
Yasuto Murayama (National Institute of Genetics)
Miki Yamamoto-Hino (Rikkyo University)
Miyako Shiraishi (Kyushu University)
Ryusei Yoshida (Kyushu University)

In nuclei, timely replication and precise segregation of the genome are ensured by the regulated assembly of large protein-DNA complexes on the genome with potential higher-order structures and proper chromatin architecture. Recent advances in structure prediction, mathematical modeling, and in vitro reconstitution have revised classical models. The spatiotemporal dynamic regulation of genome functions and interactions with diverse macromolecules are hot issues. This session will discuss the latest progress in the conservation and diversity of genome maintenance mechanisms across biological domains.

Tomohisa Toda (Friedrich-Alexander Universitat Erlangen-Nurnberg/Max-Planck-Zentrum fur Physik und Medizin/Deutsches Zentrum fur Neurodegenerative Erkrankungen e. V. (DZNE))
Carina Hanashima (Waseda University Faculty of Education and Integrated Arts and Sciences )
Goichi Miyoshi (Gunma University Graduate School of Medicine)
Daichi Kawaguchi (Graduate School of Pharmaceutical Sciences, The University of Tokyo)
Itaru Imayoshi (The Graduate School of Biostudies, Kyoto University)

During brain development, neural stem cells undergo differentiation into specific types of neurons and glial cells in a developmental-time-dependent manner. Despite the precision of the developmental schedule, the mechanisms governing this 'timer' remain largely unclear. Furthermore, disruptions in the precise timing of cell fate decisions have been implicated in the onset of neurodevelopmental disorders associated with aberrant brain size. This symposium aims to discuss the latest insights into the mechanisms governing cell fate determination during brain development, with a particular focus on their implications for neurodevelopmental disorders.

Atsushi Yokoyama (Tohoku University Graduate School of Medicine)
Shun Sawatsuhasi (Institute for Advanced Medical Sciences, Tokushima University)
Je-Yong Choi (School of Medicine, Kyungpook National University)
Zhao Yue (Department of Cell Biology, China Medical University)
Takahiro Sawada (Graduate School of Life Science and Technology, Iryo Sosei University)

Nuclear receptors (NRs) for steroid hormones/fat-soluble vitamins play pivotal roles in many physiological events, acting as ligand-dependent transcriptional factors. More recently, under various pathological conditions, NRs have been proved to modulate transcriptional and epigenetical processes. This symposium exchanges unpublished findings of NR function in sex-hormone-dependent cancers, skin/bone disorders and metabolic syndromes by inviting foreign experts and young domestic researchers. Thereby, current and forthcoming ideas to decipher physiological and pathological functions of NRs are expected to be shared with all of the related researches.

Michihiro Igarashi (Niigata University)
Toshihide Yamashita (Osaka University)
kinichi Nakajima (Kyushu University)
Minako Ito (Kyushu University)
Airi Jou (Juntendo University)
Kazunobu Sawamoto (Nagoya City University)

Cerebral vascular diseases often cause severe sequelae and recurrence with a poor prognosis, and are a major cause of the need for nursing care. In addition to cerebral infarction, age-related neurodegenerative diseases such as dementia also cause loss of nerve cells and progression of symptoms. On the other hand, it has become clear that new neurons are replenished to replace the lost ones in order to repair the damaged brain. In this symposium, we will gather researchers who aim to elucidate both the mechanisms of brain damage progression and repair at the molecular cellular level, and provide the latest information.

Sayuki Hirano (National Institutes of Natural Sciences, Exploratory Research Center on Life and Living Systems (ExCELLS))
Tetsuhisa Otani (Tokyo Metropolitan University)
Toshihiko Fujimori (National Institute for Basic Biology)
Daiji Kiyozumi (Research Institute of Environmental Medicine, Nagoya University; Japan Science and Technology Agency)
Keiko Maeda (Nagoya University Hospital)
Satoshi Konishi (Kyoto University)

Epithelia form luminal structures and act as a barrier to segregate the internal milieu from the external environment and perform essential functions such as epithelial transport. Epithelial structure and function are dynamically regulated during development, different life stages, or pathological conditions. In this symposium, we will introduce cutting-edge research on the dynamics and homeostasis of epithelial tissues, and discuss the regulatory mechanisms of the dynamics and homeostasis of epithelia.

Gloria Brar ( University of California, Berkeley)
Jonathan Bohlen (Necker hospital for sick children)
Sihan Li (Institute of Medical Science, University of Tokyo)
Kensuke Ishiguro (Graduate School of Engineering, University of Tokyo)
Akinobu Matsumoto (Graduate School of Science, Nagoya University)
Shinichi Nakagawa (Faculty of Pharmaceutical Sciences, Hokkaido University)

RNA is translated into proteins, and recent findings have revealed complex regulation of this process. Changes in RNA splicing and modifications produce different translation patterns. RNA does not necessarily produce single proteins, but rather multiple ORFs are translated. The translation balance of these multiple ORFs varies among tissues and under various conditions. Such balance is precisely regulated, and defects in the regulatory system cause diseases. Furthermore, translation can be stalled by errors, which is rescued by specific mechanisms. We will present the latest findings on these diverse regulations of RNA production, modification, and translation.

Yoshitaka Kondo (Tokyo Metropolitan Institute for Geriatrics and Gerontology)
Ayami Sato (Toyo University)
Koji Fukui (Shibaura Institute of Technology)
Kotaro Azuma (The University of Tokyo)

Nutrition is important for improving health, preventing age-related diseases, and extending healthy lifespans. Dietary interventions, especially since we choose to eat them every day, have a practical and ripple effect on controlling aging. It is therefore necessary to understand the anti-aging effects of these nutrients. In this symposium, we will invite experts in the field of "Nutrition and Aging" to present and discuss the latest research results on the various functions of vitamin C, E, and K and their relationship with aging, as well as the balance of the three macronutrients (proteins, lipids, and carbohydrates) and metabolic health.

Kazunari Akiyoshi (Graduate School of Medicine, Kyoto University)
Yusuke Sato (Graduate School of Science, Tohoku University)
Yusuke Yoshioka (Institute of Medical Science, Tokyo Medical University)
Yoshimasa Kawaguchi (Institute for Chemical Research, Kyoto University)
Ikuhiko Nakase (Graduate School of Science, Osaka Metropolitan University)

This symposium will focus on biological secretory membrane vesicles for understanding of their contaminant molecular behavior including disease progression and the challenge of chemical control. The planned lectures include analysis of sugar chains on secreted vesicles that participate in complex intercellular communication, a detection system using membrane curvature recognition peptides, functional molecular modification for new functionalization of vesicle membranes, and hybrids with artificial systems for DDS applications. The lectures will be given by up-and-coming top-runner researchers, and there will be a discussion on the possibility of explosive technology fusion.

Satoshi Ninagawa (Biosignal Research center KOBE University)
Katagiri Toyomasa (National Institute of Biomedical Innovation, National Institutes of Biomedical Innovation, Health and Nutrition)
Ayano Satoh (Okayama University)
Yuji Kashiwakura (Department of Biochemistry, Jichi Medical University School of Medicine )
Kohji Yamada (The Jikei University, Department of Biochemistry)
Hirokazu Yagi (Nagoya City University)

In the secretory pathway, organelles such as the ER and Golgi play an essential role, and their function is elaborately regulated. It is evident that disruption of homeostasis or abnormal utilization of this secretory pathway is involved in the pathogenesis of diseases. This symposium brought together researchers with the latest insights into the detailed molecular mechanisms of the secretory pathway, and the etiology and therapeutic strategies for diseases such as cancer and hemophilia, providing an opportunity to deepen our understanding of the secretory pathway from basic to applied research.

Ken Sato (Gunma University, Institute for Molecular and Cellular Regulation)
Naonobu Fujita (Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology)
Masayuki Oginuma (RIKEN Center for Biosystems Dynamics Research)
Tetsuya Takano (Kyushu University Institute for Advanced StudyPRESTO, Japan Science and Technology Agency)
Kaori Ishikawa (Faculty of Life and Environmental Sciences, University of Tsukuba)

Innovations in analytical technology have recently made it possible to analyze complex biological phenomena that were previously difficult to analyze, transcending boundaries from molecules to organelles, cells, and even the individual level. In this symposium, we will invite leading scientists who are challenged to discover and elucidate new phenomena in higher biological functions such as development, body homeostasis maintenance, and brain functions by using various model organisms. We will share and discuss recent advances in these phenomena from the molecular to the cell/organism level.

Saori Shinoda (Faculty of Life Sciences, Kyoto Sangyo University)
Yoshitaka Kurikawa (Graduate School of Medicine, The University of Tokyo)
Natsuki Shinoda (Graduate School of Pharmaceutical Sciences, The University of Tokyo)
Ziyi Li (School of Engineering, The University of Tokyo )
Shohei Fujii (Medical Institute of Bioregulation, Kyushu University)
Shintaro Fujimoto (Faculty of Science, Yamagata University)
Keisuke Mochida (Institute of Innovative Research, Tokyo Institute of Technology)

Recent breakthroughs in CRISPR/Cas9, AlphaFold, and single-cell analysis are ushering in a new era in biology, bringing both excitement and challenges. This symposium aims to bring together early career researchers skilled in these technologies to share the latest in organelle research. It will focus on discussing the challenges and innovative approaches to applying the technologies, and will provide valuable insights for those involved in technology development, as well as enhance understanding and collaboration in the field.

Mitsuo Maruyama (Geroscience Research Center, Research Institute, National Center for Geriatrics and Gerontology)
Jaewon Lee (College of Pharmacy, Pusan National University)
Naotaka Izuo (Research Center for Advanced Science and Technology, The University of Tokyo)
Yuhei Mizunoe (Laboratory of Molecular Pathology and Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science)
Yoshimi Nakagawa (Institute of Natural Medicine, University of Toyama)
Naoki Ito (National Center for Geriatrics and Gerontrogy)
Ryoya Takahashi (Department of Biochemistry, Faculty of Pharmaceutical Sciences, Toho University)

The aging process is interrelated with many internal and external factors, and the diversity of the elderly regulates individual aging more than human universal factors. It is extremely valuable to carry out basic aging research with scientific evidence on the aging factors or mechanisms for age-related diseases such as dementia and sarcopenia. Therefore, we here discuss how aging research results can lead to the healthy life expectancy extension in the view of novel geroscience research, especially with young speakers.

Yohei Hizukuri (Institute for Life and Medical Sciences, Kyoto University)
Terukazu Nogi (Graduate School of Medical Life Science, Yokohama City University)
Toru Okamoto (Juntendo University)
Taisuke Tomita (Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo)
Akio Fukumori (Osaka Medical and Pharmaceutical University)
Issei Omura (Hiroshima University Department of Biochemistry, Graduate School of Biomedical and Health Sciences)

Intramembrane proteolysis, a process catalyzed by intramembrane proteases, regulates the function of membrane proteins and transmembrane signaling in many organisms. Its deficiency causes several diseases including neurodegenerative disorders and cancer. This process is also involved in the infection and virulence of pathogens such as viruses, bacteria, and protozoa. These properties of intramembrane proteolysis make it a potential and promising therapeutic target. In this symposium, we will present our recent studies on this and related processes, and discuss them from a broad perspective, ranging from molecular basis to medical applications such as drug discovery.

Takako Chikenji (Department of Health Sciences, Hokkaido University)
Michihito Kono (Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine, Hokkaido University)
Naoya Kataoka (Department of Integrative Physiology, Nagoya University Graduate School of Medicine/Institute for Advanced Research, Nagoya University)
Noriko Komatsu (Medical Research Institute, Tokyo Medical and Dental University )
Yosuke Isobe (RIKEN Center for Integrative Medical Sciences)

It has been revealed that chronic inflammation plays a role in the development of various diseases. Recent advances in single-cell analysis have unveiled complex interactions not only among immune cells but also involving diverse cell types, including senescent cells, neuronal cells, and fibroblasts. Additionally, there is growing recognition of the significance of cellular metabolism within intercellular networks. This symposium will highlight the latest research on chronic inflammatory diseases caused by diverse cellular networks and their disruptions. The goal is to deepen discussions on the mechanisms of disease onset and progression, as well as explore therapeutic possibilities.

Atsuo Sasaki (University of Cincinnati College of Medicine, Keio University, Hiroshima University)
Koh Takeuchi (The University of Tokyo)
Toshiya Senda (Institute of Materials Structure Science, High Energy Accelerator ResearchOrganization, Structural Biology Research Center (SBRC))
Atsushi Kawaguchi (University of Tsukuba)
Kensuke Tateishi (Yokohama City University)
Satoshi Arai (Kanazawa University)
Miki Senda (Institute of Materials Structure Science, High Energy Accelerator ResearchOrganization, Structural Biology Research Center (SBRC))
Ken Iwatsuki (Tokyo University of Agricurture)

The aim of this symposium is to challenge the conventional paradigm of metabolic biochemistry and to deepen our understanding of cellular function through the analysis of metabolic enzymes in the context of physiological conditions.Breaking away from the conventional presentation format, the speakers will exchange stories and assemble a single story. The aim is to convey to students,young researchers and early career scientists the importance and fun of working as a team, leading a sensational symposium.

Koji Taniguchi (Hokkaido University)
Sergei Grivennikov (Cedars-Sinai Medical Center)
Tomohiko Okazaki (Hokkaido University)
Takatsugu Ishimoto (Japanese Foundation for Cancer Research)
Takashi Mino (Kyoto University)

Cytokines play important roles in many diseases, including cancer. In this symposium, cytokine experts will gather to present the latest research results on cytokines and share new developments in the role of cytokines and cytokine signaling pathways. The impact of findings from these studies on the development and progression of various diseases will also be discussed. Furthermore, by sharing innovative and cutting-edge findings, we aim to discuss the development of new preventive and therapeutic strategies targeting cytokines.

Ryoji Nagai (Department of Agriculture, Tokai University)
Yasuhiko Yamamoto (Graduate School of Medical Sciences, Kanazawa University)
Kiyotaka Nakagawa (Tohoku University Graduate School of Agricultural Sciences)
Nana Katsuya (Department of Agriculture, Tokai University)
Yoahikazu Yonei (Department of Medical Life Systems, Doshisha University)
Casper Schalkwijk (Maastricht University)

Glycation, a non-enzymatic process where reducing sugars bind to proteins, plays a significant role in various physiological and pathological processes, and leads to the formation of advanced glycation end products (AGEs). Recent studies have revealed intricate associations between AGEs and inflammation, notably through the receptor for AGEs (RAGE), as well as AGEs formation via lipid oxidation and post-translational modifications stemming from mitochondrial dysfunction. In this symposium, we aim to present the role of non-enzymatic post-translational modifications related to AGEs in inflammation, aging, and age-related diseases.

Jiro Harada (Kurume University School of Medicine)
Chihiro Azai (Faculty of Science and Engineering, Chuo University)
Masakazu Sugishima (Kurume University School of Medicine)
Yu Hirose (Graduate School of Engineering, Toyohashi University of Technology)
Moritoshi Sato (Graduate School of Arts and Sciences, The University of Tokyo)

The diversity of the functions in compounds that possessing the tetrapyrrole structure is ‘awesome'. For instance, the tetrapyrrole pigments such as heme and chlorophyll are used for oxygen transport, enzymatic reaction, and photosynthesis. In addition, bilins where the photosensory proteins such as phytochrome contains have tetrapyrrole backbone. For the biosynthesis of these pigments, various modifications are made to the tetrapyrrole backbone, such as metal insertion/deletion and redox reactions. This symposium covers a variety of topics regarding the recent advances in the biochemistry of tetrapyrrole biosynthesis and its application such as an optogenetics tool.

Yuki Ohkawa (Osaka International Cancer Institute, Research Center)
Yuta Shirogane (Department of Molecular Virology, Tokyo Medical and Dental University)
Kentaro Hirose (ational Cerebral and Cardiovascular Center)
Takahito Miyake (Department of Systems Biology, Division of Medicinal Frontier Science, Graduate School of Pharmaceutical Sciences, Kyoto University)
Satoshi Toda (Kanazawa University)

Proteins, lipids, and sometimes RNAs are modified with glycans. Glycan analysis at the molecular level is not favored due to the high diversity of glycans and the complicated analysis methods required. Therefore, many queries remain about the function of glycans in most physiological events. In this symposium, young scientists working on glycobiology, virology, embryology, chronobiology, and cell engineering will present their latest exciting data and discuss the action points of glycans. The organizers hope that this symposium would encourage the progress of attendee's research.

Takuji Oka (Sojo University)
Hiroto Hirayama (RIKEN)
Takeshi Ishimizu (Ritsumeikan University)
Mari Ogawa-Ohnishi (Nagoya University)
Kiyotaka Fujita (Kagoshima University)
Yoshimi Haga (Japanese Foundation for Cancer Research)

Glycosylation, a post-translational modification conserved in whole kingdoms, plays a pivotal role in various biological processes. While the detailed pathway for the biosynthesis/degradation of the glycans and their functions have been well-studied in human and some model organisms, these remain to be clarified in various organisms. To comprehensively understand the common functions of glycans across species and their unique properties within each species, it is essential to accumulate knowledge of their functions and structures in a wide range of species. This symposium will highlight cutting-edge research on glycan/carbohydrate-related enzymes and structures in diverse species.

Fumiki Katsuoka (Tohoku University)
Akiko Kobayashi (Kyoto University)
Takafumi Suzuki (Tohoku University)
Toru Sengoku (Yokohama City University)
Tsunehiro Mizushima (University of Hyogo)
Kanae Yumimoto (Kyusyu University)

In response to various stresses such as ROS, electrophilic toxins, and inflammation, the KEAP1-NRF2-sMAF system regulates the expression of genes involved in cellular defense. Its dysfunction is implicated in diverged pathologies including the onset and progression of various diseases and the malignancy of cancer. Drug discovery targeting this system is actively underway, with some already approved and others expected to be utilized clinically in the future. In this symposium, researchers investigating the mechanism of the KEAP1-NRF2-sMAF system will share the latest findings, comprehend the overall picture of this system, and aim to open new doors in both basic science and drug discovery.

Hirokazu Arimoto (Tohoku University)
Yuko Fukata (Nagoya University)
Hideaki Morishita (Kyushu University)
Shunsuke Shimobayashi (Kyoto University)
Hitoshi Nakatogawa (Tokyo Institute of Technology)
Nobuo Noda (Hokkaido University)

In cells, proteins and nucleic acids exert their functions by dynamically repeating assembly and disassembly through liquid-liquid phase separation. Similarly, in biological membranes, lipid molecules and membrane proteins are known to assemble two-dimensionally to form microdomains and exert their functions. Recent studies have revealed that these processes influence each other and play important physiological functions in cooperation. In this symposium, we share the latest findings of cooperation of heterogenous molecules at the membrane interface and discuss their roles in autophagy and other biological phenomena.

Pattama Wiriyasermkul (Department of Biological Chemistry, Faculty of Agriculture, Iwate University)
Yongchan Lee (Graduate School of Medical Life Science, Yokohama City University)
Haruo Ogawa (Graduate School of Pharmaceutical Sciences, Kyoto University)
Atsuko Yamashita (Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University)
Ai Niitsu (RIKEN Center for Biosystems Dynamics Research)

Membrane transport proteins selectively import/export molecules across cell membranes and are essential for our lives. Mutations and disruptions of these lead to serious diseases, making them crucial targets for understanding life and meeting social needs. In this symposium, we aim to bring together frontrunners of membrane transporter research from various fields (functional and structural analyses, molecular dynamics, and de novo design) and provide a seamless environment to transcend the boundaries of research areas. Together with audiences, we wish to discuss the "integrated understanding" of “Makuyusoutai-gaku" and its future.

Susumu Goto (Research Organization of Information and Systems)
Yoshiki Yamaguchi (Tohoku Medical and Pharmaceutical University)
Akira Togayachi (Soka University)
Yusuke Matsui (Nagoya University)
Katsuyuki Yugi (RIKEN Center for Integrative Medical Sciences)

In the biochemistry field, a large amount of experimental data has been accumulated and the results of these analyses have been utilized in synthesis and application, etc. On the other hand, the latest technology of bioinformatics is collecting and opening various data. For the progression of life science, it is necessary to promote comprehensive research integrated with informatics in many life science fields. In fact, gene expression analysis results from single cells to cancer have been used for integrated understanding of diseases. In this symposium, we will introduce the state-of-the-art in bioinformatics and show examples of fusion implementation in the field of biochemistry.

Yukiko Hagino (Kyushu University)
Takashi Yoshimura (Nagoya University)
Kazu Kikuchi (National Cerebral and Cardiovascular Center)
Nobuyuki Shimizu (Oita University)
Tohru Ishitani (Osaka University)

The fish model is enabling “challenge the unknowns of life science" by combining the analytical advantages of in vivo imaging and systems biology with the rapidly developing genome editing and omics technologies. In this symposium, we will present research aimed at understanding seasonal rhythms and seasonal adaptation mechanisms, the diversity of secondary sexual characteristics, aging, cardiac regenerative capacity, and rare diseases, using fish species such as medaka, zebrafish, killifish, and Danionella. We hope that participants will experience a new future of biochemistry opened up by fish models, and we look forward to the expansion of fish users in biochemistry researchers.

Kanae Ando (Tokyo Metropolitan University)
Ayako Tonoki (Chiba University)
Kotaro Furusawa (Department of Biological Sciences, Graduate School of Science, The University of Tokyo)
Shinya Yamamoto (Baylor College of Medicine)

Drosophila has contributed to understanding pathogenic mechanisms of human diseases and drug discovery as a model organism utilizing a wealth of genetic tools. Its usefulness is further enhanced by recent tools such as the integration of disease gene information and comprehensive transgenic collections to "humanize" Drosophila. In this symposium, we will discuss the strengths and developments of this approach through the latest resources in Drosophila and recent achievements in elucidating the pathogenesis of complex neurological diseases.

Akimitsu Konishi (Gunma University)
Koh Nakayama (Asahikawa Medical University)
Shinjiro Hino (Kumamoto University)
Takahiro Ito (Kyoto University)
Soshiro Kashio (The University of Tokyo)
Norio Suzuki (Tohoku University)

2-OG/α-KG (2-oxoglutarate/α-ketoglutarate), a metabolite of the TCA cycle, is an essential substrate not only for energy metabolic enzymes but also for various enzymatic reactions such as oxygenase, hydroxylase, aminotransferase, and demethylase reactions. In this session, we are pleased to have speakers who are conducting cutting-edge research on various biological reactions regulated by 2-OG. We look forward to lively discussions.

So Iwata (Kyoto University)
Osamu Miyashita (RIKEN)
Shigehiko Hayashi (Kyoto University)
Takahiro Kosugi (Institute for molecular Science)
Yuki Goto (The University of Tokyo)
Kazuyoshi Murata (ExCELLS)

We would like to deepen our understanding of what experimental and computational science should do in structural biology. We would like to discuss what should be determined experimentally and what should be left to computation, what data computational scientists are looking for from experimental scientists, and what we can do by integrating these two fields that were not possible before.

Miho Kobayashi (Tokyo Medical and Dental University)
Hiroaki Daitoku (Tsukuba University)
Akira Kawamura (Jikei University School of Medicine)
Hirotaka Takahashi (Ehime University)
Tomohisa Sakaue (Ehime University)

The majority of synthesized human proteins undergo post-translational modifications such as phosphorylation and ubiquitination, which significantly alter cellular functions. The signal networks driven by post-translational modifications of proteins are exceptionally diverse. In this symposium, we focus on the post-translational modification signals of newly synthesized proteins and present the latest research findings on diverse protein modification pathways such as ubiquitination, neddylation, methylation and tyrosine dephosphorylation. Our aim is to comprehend the significance of post-translational modification dynamics in transforming cellular functions.

Yuki Nakamura (RIKEN Center for Sustainable Resource Science )
Koichi Kobayashi (Department of Biology, Graduate School of Science, Osaka Metropolitan University)
Hsou-min Li (Institute of Molecular Biology, Academia Sinica )
Miyo, T Morita (Division of Plant Environmental Responses, National Institute for Basic Biology)

Sessile plants have equipped a sophisticated mechanism to maintain the cellular function under changing environment. Recent studies revealed an involvement of plastids, a plant-specific organelle, in this process. This symposium aims to discuss recent advances in the understanding of organelle function in plant environmental response, with particular focus on the relationship with the biological membranes.

Yoichi Otsuka (Osaka University)
Tomomi Hashidate-Yoshida (National Center for Global Health and Medicine)
Shinji Miura (University of Shizuoka)
Kazuko Saeki (Juntendo University)
Yuta Shimanaka (UCLA)

Phospholipids consist of more than a thousand of molecules. These various species have been postulated to have a variety of biological functions. However, the majority of the functions remain elusive. By recent discovery of lipid-related genes and their genetic modification as well as innovations in lipidomic technology, we have been able to approach this unexplored area. Now, it is becoming clear that phospholipid functions depend on both polar heads and fatty acids. In this symposium, we will discuss the new technologies and the unveiled new phospholipid functions using these technologies.

Fan-Yan Wei (IDAC, Tohoku University)
Yukio Kawahara (Graduate School of Medicine, Osaka University)
Satoshi Uchida (Medical Research Institute, Tokyo Medical and Dental University)
Osamu Takeuchi (Graduate School of Medicine, Kyoto University)

Recently, mRNA drugs have attracted attention as a new modality. However, foreign RNAs induce immune responses, and their regulation poses many challenges. In this symposium, we would like to organize lectures on RNA and immune regulation from many perspectives, including modification and editing of mRNA and its relationship with RNA-binding proteins, and also discuss new directions in RNA drug discovery.

Chanhee Kang (School of Biological Sciences, Seoul National University)
Shota Yamauchi (Grad. Sch. of Pharmaceut. Sci., Univ. of Tokyo)
Yasuhiro Nakano (Integrated Systems of Aging Research Unit, Institute for Frontier Science Initiative, Kanazawa University)
Shimpei Kawamoto (Department of Molecular Microbiology, Research Institute for Microbial Diseases, Osaka University)
Toru Minamino (Department of Cardiovascular Biology and Medicine,Juntendo University Graduate School of Medicine)
Makoto Nakanishi (Division of Cancer Cell Biology, The Institute of Medical Science, The University of Tokyo)

The analysis of mechanisms controlling the lifespan of organisms has greatly expanded from research using model organisms such as yeast and nematodes to studies involving mammals like mice and marmosets. Particularly, with the advancement in cellular senescence research, the analysis of the fundamental mechanisms of aging and the elucidation of the mechanisms behind age-related diseases have dramatically progressed. Recently, there is significant attention on senolytics, controlling senescent cells in humans. In this symposium, we aim to deepen the understanding of the biochemistry of aging by sharing and discussing the latest findings in aging and cellular senescence research.

Akira Kikuchi (Center for Infectious Disease Education and Research, Osaka University)
Akiko Takahashi Takahashi (Cancer Institute, Japanese Foundation for Cancer Research)
Yasuhiro Yamada (Graduate School of Medicine, The University of Tokyo)
Noriko Gotoh (Cancer Research Institute, Kanazawa University)
Keiichi Nakayama (Tokyo Medical and Dental University)

Descriptions of cancer began with human breast cancer in the B.C. In the early 1900s, the existence of a virus that causes chicken sarcoma was identified. The glucose metabolism biased toward the glycolytic system in cancer cells was demonstrated. In the 1970s, it was shown that gene mutations in normal cells cause cancer. In the 2000s, with the completion of the genome project and the development of technologies, cancer is now considered to be a disease of qualitative and quantitative changes in genes. However, the understanding does not necessarily lead to treatment. Here, we share the current state of cancer research and treatments based on the biological characteristics of cancer.

Akiyuki Nishimura (National Institute for Physiological Sciences)
Shohei Murakami (Tohoku University Graduate School of Medicine)
Vladimir Bayaheu (Tohoku University Graduate School of Medicine (Helmholtz))
Liron Bar-Peled (Massachusetts General Hospital)
Kei Wada (Miyazaki University)
Haruna Tani (Institute of Development, Aging and Cancer, Tohoku University)

Sulfur is an element that has been a driving force in the history of life on Earth. We aim to understand life in a new dimension by focusing on the supersulfides and its related molecules, which recent technical advances have revealed to be universal biomolecules. Ongoing studies have identified important roles of supersulfides in intracellular organelles such as mitochondria, lysosomes, and endoplasmic reticulum, and have revealed that supersulfides play a fundamental role in redox reactions in the cell. In this symposium, emerging researchers will introduce their latest research on the biological phenomena mediated by supersulfides and related molecules.

Yosuke Ohba (Keio University Faculty of Pharmacy)
Nozomu Kono (Graduate School of Pharmaceutical Sciences, the University of Tokyo)
Hitoshi Shimano (Department of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba)
Taki Nishimura (Dept. of Biochem & Mol. Biol., Faculty of Med., The Univ. of Tokyo )
Hui-Hsing Hung (RIKEN CBS (former affiliation))

With the development of lipidomics by mass spectrometry, it has become clear that there are more than several thousand different types of lipid molecules in living organisms. The composition of lipid molecules differs among tissues, cell types, and intracellular organelles, and the diversity of lipid molecules (LipoQuality) is important factor in defining the individuality of cells and organelles. Alterations in LipoQuality are observed in various diseases, such as metabolic diseases and cancer, and are attracting attention as a background factor of diseases. In this symposium, we will discuss the current and future perspectives of LipoQuality research that regulates cellular functions.

Taiichiro Shirai (Immunology Frontier Research Center, Osaka University)
Jun Tsuyama (Tokyo medical and dental university)
Junta Imai (Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine)
Asako Shindo (Department of Biological Sciences, Osaka University)
Naoko Kayama (Institute for Advanced Co-Creation Studies, Osaka University)
Yukako Oda (CiRA, Kyoto University)

In order for living organisms to adapt to the surrounding environment and remodel their tissues, environmental factors that trigger these factors and elaborate molecular and cellular mechanisms to respond correctly to the environment are indispensable. This symposium is comprised of relatively young researchers who have recently elucidated the adaptation and repair mechanisms of living organisms at the molecular and cellular levels. All of these are the latest research results conducted from a multifaceted perspective and are presented by researchers who will lead biochemistry in the future. This symposium can predict the future development of biochemistry.

Hiroaki Tachiwana (The Cancer Institute of JFCR)
Atsushi Okabe (Chiba University)
Naoko Hattori (Hoshi University)
Hitomi Matsuzaki (University of Tsukuba)
Tomohiko Akiyama (Yokohama City University)
Takashi Fukaya (The University of Tokyo)

A cell identity is characterized by the expression of certain genes. Consequently, cells need to express particular genes at the appropriate timing and in sufficient quantity. However, how these processes are controlled remains unclear. Recent advances in analytical techniques have revealed that chromatin structure correlates with the state of gene expression. It is therefore crucial to understand the mechanisms of gene expression governed by chromatin structure in order to unravel genome regulation. In this symposium, we will present the latest findings on the mechanisms of gene expression regulations revealed through techniques such as biochemistry, genome analysis, and imaging.

Yuta Amagai (Medical institute of Bioregulation, Kyushu University)
Chika Tsutsumi (Faculty of Life Sciences, Kyoto Sangyo University)
Yoshiaki Furukawa (Department of Chemistry, Keio University)
Hijiri Oshio (Faculty of Science, Gakushuin University)
Takashi Toyama (Graduate School of Pharmaceutical Sciences, Tohoku University)
Masaki Okumura (Frontier Research Institute for Interdisciplinary Sciences,Tohoku University)

Cellular protein quality control systems operate by elaborate mechanisms, such as the promotion of productive protein folding, recognition of misfolded proteins, and their recruitment into the degradation pathways. These systems rely on the intracellular chemical environment, the disruption of which impairs proteostasis, leading to aging and various diseases. Recently, it has been revealed that the fantastic "concert" of redox and metal ions forms the foundation of proteostasis. To gain deep insights into the interplay between the intracellular chemical environment and protein quality control, this symposium highlights the latest findings in the research field of chemical proteostasis.

Noriyuki Matsuda (Tokyo Medical and Dental University)
Yuhei Araiso (Kanazawa University)
Takaya Ishihara (Shimane University)

The diverse functions and in vivo behavior of mitochondria will be discussed, especially from a molecular perspective, including dynamics through membrane fusion and fission, and quality control through recognition and degradation of mitochondrial dysfunction, among other recent research results.

Makoto Sato (Mathematical Neuroscience Unit, Institute for Frontier Science Initiative, Graduate School of Medical Sciences, Kanazawa University)
Masato Sawada (Department of Developmental and Regenerative Neurobiology, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences)
Asami Kawasaki (Department of Neurochemistry and Molecular Cell Biology, Niigata University School of Medicine and Graduate School of Medical/Dental Sciences)
Sachi Inagaki (Laboratory for Morphogenetic Signaling, RIKEN Center for Biosystems Dynamics Research )
Takeshi Kawauchi (Department of Adaptive and Maladaptive Responses in Health and Disease, Graduate School of Medicine, Kyoto University)

In the development of multicellular organisms, each cell acquires a unique morphology, which requires proper regulation of the organelle morphology and positioning. For example, cell migration involves dynamic changes of nuclear morphology and ER forms functional contact sites with various organelles and endosomes. In this symposium, we invite outstanding researchers for cell and organelle morphologies in the broad fields; from biochemistry to mathematical science. We will discuss the regulatory mechanisms and physiological function of morphogenesis in cell and subcellular levels.

Atsushi Saito (Department of Biochemistry, Institute of Biomedical & Health Sciences, Hiroshima University)
Hiromi Tamada (Department of Anatomy, Graduate School of Medical Sciences, University of Fukui)
Yuki Ohsaki (Department of Anatomy (I), School of Medicine, Sapporo Medical University)
Fubito Nakatsu (Department of Neurochemistry and Molecular Cell Biology, Niigata University School of Medicine and Graduate School of Medical/Dental Sciences)
Naoya Murao (Laboratory of Biochemistry and Molecular Biology, Department of Medical Sciences, University of Miyazaki)

Endoplasmic reticulum (ER) acts as a starting point for the regulations of diverse vital phenomena. It is assumed that ER functions and the signal-sensing and -responses should not be uniformly in all its area. This symposium introduces the late-breaking findings of the dynamics of biological substrates, the changes of the membrane, and signal-responses revolved at the specialized regions of ER membrane including the contact sites between the membrane of ER and other organelles. We also discuss molecular mechanisms linking the disturbances of these machineries with the pathogenesis.

Yasushi Tamura (Faculty of Science, Yamagata University)
Yusuke Hirabayashi (Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo)
Michiko Shirane (Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University)
Hiderou Yoshida (Department of Molecular Biochemistry, Graduate School of Life Science, University of Hyogo.)
Sho Suzuki (Nanyang Technological University Singapore)
Satoko Shinjo (Department of Biology, University of Padova)

Organelles dynamically change their quantity, morphology, and function in response to various conditions, contributing to the maintenance of an appropriate intracellular environment. Recently, it has been recognized that membrane contact sites (MCSs), where different organelle membranes are in close proximity, play crucial roles in the functional reorganization of organelles. However, it is still unclear how MCSs are formed and what their physiological significance is. In this symposium, researchers focusing on MCSs will gather to present the latest advancements in this field.

Ayumu Sugiura (Graduate School of Medicine, Juntendo University)
Shun Nagashima (School of Life Sciences, Tokyo University of Pharmacy and Life Sciences)
Atsuko Kasahara (Graduate School of Life Sciences, Tohoku University)
Shohei Uchinomiya (Graduate School of Pharmaceutical Sciences, Kyushu University)
Sho Aki (Division of Integrative Nutriomics and Oncology, RCAST, The University of Tokyo)
Isshin Shiiba (Department of Life Science, Faculty of Science, Gakushuin University)

In eukaryotic cells, finely tuned organelle dynamics play a pivotal role in maintaining intracellular homeostasis. Organelle superstring theory is a research field to understand not only individual organelles and their states at a certain time point, but also the relationships between organelles and their changes over time in a multidimensional manner. In this symposium, we will introduce the latest findings on organelle matching mechanisms, their roles in cell differentiation, and novel functional evaluation methods. We also hope that the symposium will serve as a venue for matching researchers in diverse fields and provide an opportunity for the creation of new fields and collaboration.

Kiyotoshi Sekiguchi (Institute for Protein Research, Osaka University)
Hiromi Yanagisawa (Tsukuba Advanced Research Alliance, University of Tsukuba)
Nagako Yoshiba (Graduate School of Medical and Dental Sciences, Niigata University)
Kei Hashimoto (Institute for Human Life Science, Ochanomizu University)
Junpei Kuroda (Graduate School of Frontier Biosciences, Osaka University)
Azusa Dobashi (Graduate School of Medical and Dental Sciences, Niigata University)

In the late 1900s, after the discovery of extracellular matrix (ECM) molecules and the subsequent pursuit of its functional analysis, biochemical analysis progressed, and the clarification of its actual state seemed to be completed. In recent years, however, innovations in analytical technology have begun to reveal new aspects of the ECM. The question is: “How is the highly organized extracellular environment that controls the behavior and fate of cells regulated?" To answer this question, this symposium will provide an opportunity to discuss the challenges and prospects of ECM research by five researchers with a passion for ECM research.

Shigehiro Ohdo (Faculty of Pharmaseutical Sciences, Kyushuu Univ.)
Takaomi Sakai (Biological Science, Tokyo Metropolitan Univ.)
Takahiro Chihara (Program of Biomedical Science, Hiroshima Univ.)
Haruhisa Kawasaki (Institute for Chronobiology, FAIS)

Recently,the molecular mechanism of circadian clock system may be explained the interaction between CLOCK proteins and clock genes.But, even in after Nobel prize in this field, We do not knows clock molecular mechanism precisely. We would take sevral topics in the clock molecular biology and discuss with peaples in floor.

Kenji Kabashima (Kyoto University)
Motoko Yanagita (Kyoto University)
Yoshiaki Kubota (Keio University School of Medicine)
Daichi Inoue (Department of Hematology-Oncology, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe)
Keiyo Takubo (National Center for Global Health and Medicine Research Institute)

The body responds to various tissue injuries by adapting or repairing tissues; however, the cell populations and molecules responsible for this process have not been fully elucidated. Tissue repair and inflammation are closely related, and the presence of inflammation facilitates or restrains tissue repair depending on the context. In this symposium, researchers in the AMED-CREST and PRIME of "Tissue adaptation and repair mechanisms" will elucidate the mechanisms of inflammation and repair from their own perspectives.

Hiroshi Inoue (Institute for Frontier Science Initiative, Kanazawa University)
Yoshiaki Yamaguchi (Faculty of Chemistry, Materials and Bioengineering, Kansai University)
Takayoshi Suganami (Research Institute of Environmental Medicine, Nagoya University)
Yumiko Oishi (Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University)

Biochemical responses regulate diverse cellular functions, encompassing metabolism, inflammation, proliferation, and cell death. Furthermore, these cellular functions are finely tuned through intercellular and interorgan crosstalk. These crosstalks are mediated by humoral factors and the nervous system, and they can be easily disrupted by changes in lifestyle. In this symposium, our aim is to share cutting-edge insights into the molecular mechanisms of intercellular and interorgan crosstalk, primarily from the perspective of the pathophysiology of lifestyle-related diseases.

Masashi Narita (University of Cambridge )
Kyoko Miura (Kumamoto University)
Masaki Mizunuma (Hiroshima University)
Takashi Nakagawa (Toyama University)
Mitsuyoshi Nakao (Kumamoto University)

The aging phenomenon is shaped by the interaction of genetic and environmental factors. “Hallmarks of Aging" (Cell, 2023) proposes 12 features which control aging while influencing each other. Particularly, metabolites generated during intracellular metabolism (acetyl-CoA, SAM, NAD+, FAD, etc.) are responsible for chemical modifications of epigenome such as acetylation and methylation. From this viewpoint, we would like to discuss cellular senescence and aging, using model organisms, to understand the basic mechanisms of aging and strategies for controlling age-related pathologies.

Junichi Tanaka (Showa University)
Yoshizumu Hirota (Shibaura Institute of Technology)
Rei Watanabe (Juntendo University)
Kenichi Nagata (Nagoya University)
Tomoaki Tanaka (Chiba University)
Kaoru Sato (Tokyo Metropolitan Institute of Gerontology)
Hideaki Matsui (Brain Research Institute, Niigata University)

Multi-faceted networks of aging signals and metabolic stresses are involved in diverse disease molecular pathophysiology, confounding cellular senescence as well as organ and individual aging. The development of single cell and spatial transcriptomics, and/or multi-omics analysis, has made it possible to understand underlying mechanisms and regulatory systems from multiple perspectives. In this symposium, under the theme of "Disease Molecular Biology Unraveling Life-Aging-Disease-Death," we will introduce pioneering research that has opened up new perspectives. We hope to deepen our discussion on future developments and possibilities.

Kazuki Hattori (Research Center for Advanced Science and Technology, the University of Tokyo)
Yuta Hiraike (Division for Health Service Promotion, the University of Tokyo)
Yuka Inaba (Institute for Frontier Science Initiative, Kanazawa University)
Fiona Louis (Graduate School of Engineering, Osaka University)
Allah Nawaz (Joslin Diabetes Center and Harvard Medical School)
Tadashi Takeuchi (Stanford University School of Medicine)

Metabolic diseases such as obesity and diabetes are risk factors for cardiovascular diseases and cancers. The liver, muscle, and adipose tissues are crucial for energy metabolism and key organs for understanding metabolic diseases. Here, young scientists will share their cutting-edge sciences driven by broad approaches, including biochemistry, molecular biology, data science, and engineering, to dissect the pathophysiology of these organs. We discuss host-microbe interactions, epigenetics, cell death, 3D culture, and iPS cell models toward future interdisciplinary collaborations.

Kensuke Shibata (Yamaguchi University)
Naoko Satoh-Takayama (RIKEN Center for Integrative Medical Sciences)
Yuki Sugiura (Center for Cancer Immunotherapy and Immunobiology (CCII), Kyoto University)
Koji Hase (Faculty of Pharmacy, Keio University)
Nobuhiko Kamada (University of Michigan)

The gut commensal bacteria consumes undigested materials, producing a diverse range of metabolites such as short-chain fatty acids, B vitamins, and indole derivatives. It is, therefore, often termed as a "hidden organ." A part of the commensal-derived metabolites function as signaling molecules for immune regulation. Furthermore, it has been increasingly recognized that certain dietary components can significantly impact immune responses by altering the balance of the microbiome. In this symposium, we aim to present the latest findings on the immune-modulating machinery by the diet-microbiome axis and delve into discussions regarding its physiological significance.

Hideki Hara (Asahikawa Medical University)
Akihisa Kato (The University of Tokyo)
Yun-Gi Kim (Keio University)
Sohkichi Matsumoto (Niigata University)
Nobuhiko Kayagaki (Genentech)

Understanding pathogen-host interactions by elucidating the biological responses of organisms in infectious diseases from a biochemical standpoint.

Yusuke Endo (KAZUSA DNA Research Institute)
Hiroshi Kimura (Micro/Nano technology center, Tokai University)
Takuma Misawa (RIMEN IMS)
Hiroyuki Hosokawa (Graduate School of Medicine, Tokai University)
Tomoaki Koga (Institute of molecular embryology and genetics, Kumamoto University)
Tiffany Horng (School of Life Science and Technology, ShanghaiTech University)

Fundamental to the phenomena of life are molecular heterogeneity and its transitions, or "fluctuations". The essence of fluctuation in the immune system lies in its ability to maintain regularity while being flexible and spontaneous, characteristics that cannot be imitated by machines. Recent findings have shown that "metabolic fluctuation" is the most important factor supporting the immune system because of its heterogeneity, variable dynamics, and nature as a carrier across multiple layers. In this symposium, we present the latest topics on the spatio-temporal interactions of the immune-metabolic system in disease and defense responses.

Motoi Kanagawa (Ehime University Graduate School of Medicine)
Yoshitsugu Aoki (The National Center of Neurology and Psychiatry)
Koji Yamanaka (Nagoya University)
Rieko Muramatsu (The National Center of Neurology and Psychiatry)
Toshio Fujimoto (iPark Institute Co., Ltd.)
Shushi Nagamori (Center for SI Medical Research, The Jikei University School of Medicine)

There are approximately 7,000 rare diseases in the world, but 95% of them have no treatment. The development of treatments for rare diseases is an urgent issue, and a movement is underway through a super-collaboration of industry-academia-government. In understanding the pathomechanisms of rare diseases, biochemistry and other basic medical and biological sciences have contributed greatly to the development of innovative therapies. In this symposium, we would like to discuss the mission of biochemistry in realizing medical care that leaves no one behind.

Arun T. John Peter (Life Sciences InstituteUniversity of British Columbia, Vancouver)
Katsumori Segawa (Department of Medical ChemistryMedical Research InstituteTokyo Medical and Dental University)
Saori Yoshii (Department of Biochemistry and Molecular BiologyGraduate School and Faculty of MedicineThe University of Tokyo)
Tetsuya Kotani (Cell Biology CenterInstitute of Innovative ResearchTokyo Institute of Technology)
Masaki Tsuchiya (Department of Integrative PhysiologySchool of Pharmaceutical SciencesUniversity of Shizuoka)

Membrane structures delineate organelles and optimize their functionalities. While much attention has been given to studying intracellular changes in proteins, the dynamics of membrane lipids have remained relatively unexplored. Recent recognition of inter- and intra-organelle lipid dynamics underscores their fundamental role in initiating signaling pathways and supporting cellular functions. This symposium aims to spotlight the tracking of membrane lipids and highlight the critical role of lipid dynamics. We invite discussions on future research directions in understanding the landscape of membrane lipid dynamics.

Kentaro Shimasaki (Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases)
Kenta Moriwaki (Department of Biochemistry, Graduate School of Medicine, Toho University)
Takeshi Noda (Laboratory of Ultrastructural Virology, Institute for Life and Medical Sciences, Kyoto University)
Takashi Nozawa (Department of Microbiology, Graduate School of Medicine, Kyoto University)
Kohei Arasaki (School of Life Sciences, Tokyo University of Pharmacy and Life Sciences)
Eiji Morita (Department of Biochemistry and Molecular Biology, Faculty of Agriculture and Life Science, Hirosaki University)

Various infectious pathogens reconstruct host organelles for their proliferation. Meanwhile, host cells prevent it by inducing innate immune responses, autophagy, or cell death. Recent advances in imaging techniques have allowed us to visualize host-pathogen interactions, facilitating elucidation of the molecular mechanisms underlying their interactions. Furthermore, advanced imaging technology will develop new methods for detecting pathogen infections. The investigators in this symposium will present their recent studies on the host organelle-relevant events for eliminating and replicating pathogens with various imaging techniques.

Yoshihiro Ujihara (Nagoya Institute of Technology, Graduate School of Engineering)
Yuki Katanosaka (Department of Pharmacy, Kinjo Gakuin University)
Kazuya Tsujita (Biosignal Research Center, Kobe University)
Yuji Hara (School of Pharmaceutical Sciences, University of Shizuoka)
Akira Murakami (School of Pharmaceutical Sciences, University of Shizuoka)
Sawako Yamashiro (Graduate School of Biostudies, Kyoto University)

The concept of resilience has been vaguely applied as a factor indicating the texture of our bodies. However, the mechanisms by which it is generated at the cellular and tissue levels remain unclear. In this symposium, resilience is defined as the ability to adapt to various stresses. In particular, we hypothesize that “critical membrane sites" are essential in creating cellular and tissue flexibility by activating mechanosensitive ion channels and remodeling the cytoskeleton. Moreover, this symposium will discuss developing novel techniques for quantifying cellular flexibility, which may expand current knowledge and establish a novel research field called “resilience biology."

Junya Hasegawa (Graduate School of Pharmaceutical Sciences, Kitasato University)
Ikuyo Ichi (Faculty of Core Research, Ochanomizu University)
Yusuke Hirata (Graduate School of Pharmaceutical Sciences, Tohoku University)
Kotaro Hama (Faculty of Pharmaceutical Sciences, Teikyo University)
Jumpei Omi (Graduate School of Pharmaceutical Sciences, The University of Tokyo)
Ayaka Ito (Research Institute of Environmental Medicine, Nagoya University)
Akiko Harauma (School of Life and Environmental Science, Azabu University)

Fatty acids are essential components of life, and their lack causes serious pathological conditions in living organisms. Although their importance has been clear for a long time, there have been no integrated studies on the dynamics and metabolism of ingested fatty acids. In this symposium, the young researchers focusing on fatty acids in Japan, will present their latest research. Since the presenters come from diverse fields such as biology, nutrition, immunology, and organic chemistry, presenters and audience members from various fields can interact in this symposium, which aims to develop into joint research and to foster interdisciplinary research through this symposium.

Tatsuhiko Hirota (Asahi Quality & Innovations, Ltd.)
Tatsuo Adachi (RIBOMIC Inc.)
Atsushi Miyashita (Teikyo University)
Masaki Ishii (Musashino University)

Industry-academia-government collaborations offer early and mid-career researchers unique access to resources and networking, vital for innovation in biochemistry. Yet, they face hurdles such as limited research freedom, IP issues, and inter-sector cultural conflicts. This symposium will explore these perspectives and challenges, seeking strategies for successful collaboration.

Yueh-hsiu Chien (Stanford University School of Medicine)
Ichita Hasegawa (Graduate School of Medicine, Chiba University)
Natsumi Awata (Medical Institute of Bioregulation, Kyushu University)
Daisuke Takahashi (Keio University Faculty of Pharmacy)
Tom Fulford (The University of Melbourne)
Eui-Cheol Shin (Korea Advanced Institute of Science and Technology)

The immune system recognizes and eliminates foreign pathogens while it becomes tolerate to self-components. However, recent studies have shown that immune cells recognize self components, which play the "beneficial" functions such as tissue repair for homeostasis. In this symposium, we will particularly focus on gd T cells and discuss their versatile functions in physiological/pathological settings.

Takanori Kigawa (RIKEN Center for Biosystems Dynamics Research)
Seizo Koshiba (Tohoku Medical Megabank Organization, Tohoku University)
Tomoyasu Aizawa (Faculty of Advanced Life Science, Hokkaido University)
Atsushi Hozawa (Division of Epidemiology, School of Public Health, Tohoku University Graduate School of Medicine)
Toshiyuki Nagai (Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University)
Yosuke Hirakawa (Division of Nephrology and Endocrinology, the University of Tokyo Hospital)
Hirohisa Izumi (Health Care & Nutritional Science Institute, R&D Division, Morinaga Milk Industry Co., Ltd.)
Wataru Sato (Research Institute for Bioscience Products & Fine Chemicals , Ajinomoto Co., Inc.)

In the life sciences, nuclear magnetic resonance (NMR) has been used in a wide range of fields, including drug discovery and structural biology, thanks to recent technological innovations and the establishment of advanced NMR research infrastructures. In medical research and health care, the use of NMR has recently expanded, especially in metabolome analysis, and is attracting worldwide attention. This symposium will focus on the latest research and development using NMR in medical research and healthcare, and new trends in these fields will also be discussed.

Yasuyuki Sakai (The University of Tokyo)
Kosuke Ino (Tohoku University)
Kotaro Doi (The University of Tokyo)
Masahiro Inoue (Kyoto University)
Kiyotaka Hitomi (Nagoya University)

Culture of animal cells is currently used as a standard experiment in life science as most presentations at this conference show data from cell culture experiments. Various culture conditions such as nutrients, osmotic pressure, pH and so on have been investigated to mimic the in vivo environment. However, concentrations and delivery of oxygen in cell culture systems have not been sufficiently investigated even though oxygen is essential for cellular energy production. In this symposium, innovative systems of cell culture for recapitulating in vivo oxygen environment and their applications will be introduced.

Keiko Nonomura (Tokyo Institute of Technology)
Keiko Kono (Okinawa Institute of Science and Technology Graduate University)
Tomonori Tamura (Kyoto University)
Michio Murata (Osaka university)
Atsushi Matsumoto (Kyushu University)
Jun Suzuki (Kyoto University)

Proteins on the membrane do not function by themselves, but form specific communities with other proteins, lipids, and organelles on and outside the membrane and cooperate with them to express their functions. Recently, the remarkable development of comprehensive analysis, imaging, and reconstitution techniques has made it possible to understand membrane dynamics at a higher resolution level. As a result, new regulatory systems of membranes are beginning to be captured. In this symposium, cutting-edge researchers who study membranes from unique angles will gather to share and discuss their research.

Yoichiro Tamori (Department of Molecular Oncology, Graduate School of Medicine, Kyoto University)
Kanji Furuya (Laboratory of Genome Damage Maintenance, Radiation Biology Center, Graduate School of Biostudies, Kyoto University)
Mayumi Seto (Faculty of Science, Nara Women's University)
Nobuhiko Nomura (Microbiology Research Center for Sustainability, Faculty of Life and Environmental Sciences, University of Tsukuba)

Mutual aid, even across species, as vital means for survival can be found from microbes to human society. Even at the cellular level, individual stress responses within a population under the same stress are more diverse than we imagined, revealing the significance of heterogeneity in cell populations for the evolution of cooperation. This symposium focuses on “populational heterogeneity" and “cooperation arising from heterogeneous populations" as a new strategy to adapt to environmental stress, to explore the relationship between “heterogeneity" and “cooperation" and its significance in the evolution of biological functions.

Tsuyoshi Osawa (RCAST, University of Tokyo)
Teppei Shimamura (Medical Research Institute, Tokyo Medial and Dental University)
Yutaka Suzuki (Graduate School of Frontier Sciences, University of Tokyo)
Yoshihiro Yamanishi (Graduate School of Informatics, Nagoya University)
Eiryo Kawakami (RIKEN)
Masamistu Konno (AIST)

Recent advancements in spatial omics and super-resolution imaging are pivotal in biochemical research, marking a significant paradigm shift. Coupled with computational and information sciences, these technologies enhance big data collection and analysis, fostering rapid progress in data-driven studies. This symposium features young researchers exploring how these approaches revolutionize understanding in biology, medicine, and disease prevention, integrating AI to push the boundaries of biochemical research further.

Shuji Mizumoto (Meijo University)
Yoichiro Harada (Osaka International Cancer Institute)
Takeo Suzuki (University of the Ryukyus)
Naoki Itano (Kyoto Sangyo University)
Tomomi Izumikawa (Ritsumeikan University)

Carbohydrates are supra-multitasking molecules that are used not only for fueling cellular metabolism, but also for regulating various biological processes and diseases by modifying proteins and lipids. Emerging evidence that stability and function of DNA and RNA are regulated by carbohydrates also highlights the importance of carbohydrate-dependent regulation of central dogma. In this symposium, we propose “glycostasis", a process that controls quantity, quality and localization of carbohydrates and their modification, and discuss how it contributes to our health and disease progression.

Shiori Sekine (Pittsburgh University)
Yoshiro Saito (Tohoku University)
Atsushi Mochizuki (Kyoto University)
Yasuteru Shigeta (Tsukuba University)
Ayako Fukunaka (Gunma University)

Based on the sequencing of the entire human genome, it is not known that metal ions bind to more than 30% of proteins in cells and play roles in many reactions that are important for biological activities. Although substantial progress has been made in recent years in the study of protein-protein interactions by combining experimental analyses with theoretical calculations and machine learning, little is known about how proteins interact with metals and how this alters protein dynamics. In this symposium, we will present our recent research on the molecular interactions between metals and proteins performed using various methods.

Itsuki Ajioka (Center for Brain Integration Research, Tokyo Medical and Dental University)
Akiko Hashimoto (Faculty of Textile Science and Technology, Shinshu University)
Koji Nagahama (Frontiers of Innovative Research in Science and Technology, Konan University)
Ken-ichi Mizutani (Graduate School of Pharmaceutical Sciences, Kobe Gakuin University)

With the advancement of the medical technology, a variety of functions to control a life phenomenon are needed to biomaterials used for medical and health care. Information sharing by the fusion of the different fields such as chemistry, physics, life sciences is necessary to develop the biomaterial based on the essential understanding of the interaction between materials and the cells. In this symposium, we will find out the knowledge to be connected for development of the innovative biomaterial from the perspectives of various academic fields, by sharing recent information about the biomaterial to expand the wide discussion that included disease and treatment.

Michiko Sekiya (National Center for Geriatrics and Gerontology)
Aya Ogata (Gifu University of Medical Science)
Shingo Tamai (RIKEN CBS/ Graduate School of Medical and Dental Sciences, TMDU)
Sumihiro Maeda (Keio University School of Medicine)

Recent approval of amyloidβ-immunotherapy opens a new era of Alzheimer's disease (AD) treatment. Advances in neuroimaging and cerebrospinal fluid and blood-based biomarkers provide accurate and sensitive diagnosis of pre-clinical AD. To unravel pathogenic mechanisms underlying continuum of AD and facilitate discovery of novel biomarkers and therapeutic targets, research utilizing human samples is critically important. In this symposium, young researchers conducting basic, translational, and clinical research will present the latest findings and discuss future perspectives of AD therapeutics.