Program
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Convener : Shinichi Yokota (Sapporo Medical University)
Speakers : Satoshi Ichikawa (Hokkaido University) , Toyotaka Sato (Hokkaido University) , Naoya Kojima (Tokai University)
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Convener : Shinichi Yokota (Sapporo Medical University) , Hideaki Higashi (Hokkaido University)
Speakers : Takahiko Toyotome (Obihiro University of Agriculture and Veterinary Medicine) , Tomoe Kitao (Hokkaido University) , Hideki Hara (Asahikawa Medical University) , Lee Ji-Won (Hokkaido University) , Shin-Ichiro Miyashita (Tokyo University of Agriculture) , Chiu Chen-Hsuan (Health Sciences University of Hokkaido) , Aiko Maeda (Hokkaido University) , Mitsuyo Kawaguchiya (Sapporo Medical University) , Torahiko Okubo (Hokkaido University)
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Convener : Symposium 2 Yusuke Minato（Fujita Health University）・Joon Haeng Rhee（Chonnam National University）
Symposium 1 9:00-12:00
Speakers：
Yoshiyuki Goto(Chiba University),Jin Kyung Kim(Keimyung University School of Medicine),Hidetada Hirakawa(Gunma University),Eui Tae Kim(Jeju National University),Hiroshi Hamamoto(Yamagata University),Seong-Tshool Hong(Jeonbuk National University),Ken-ichi Lee(National Institute of Infectious Diseases)
Poster presentation 13:00-14:30
Symposium 2 14:30-17:30
Speakers：Minho Lee(Hallym University),Kotaro Kiga(National Institute of Infectious Diseases),Seungwha Paik(Chungnam National University),Toshio Kodama(Nagasaki University),Chul-Su Yang(Hanyang University),Yukihiro Akeda(National Institute of Infectious Diseases),Moo-Seung Lee(Korea Research Institute of Bioscience and Biotechnology/University of Science and Technology)
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Convener : Takahito Toyotome (Obihiro University of Agriculture and Veterinary Medicine) , Masaya Yamaguchi (Osaka University)
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Convener : Ryo Ozuru (Fukuoka University) , Ryo Nagasawa , (Aichi Medical University) , Yuki Wakabayashi (Osaka Institute of Public Health)
Speakers : Uki Kimura (Tottori University) , So Shimoda (Tohoku University) , Noriteru Yamada (Kyoto Pharmaceutical University) , Shoko Kutsuno (National Institute of Infectious Diseases) , Natsuki Yamanaka (University of Chiba) , Momoko Kobayashi (Osaka University) , Naoki Uemura (The University of Electro-Communications)
Overview : The Wakate Colosseum for Bacteriology provides a forum for the presentation and discussion of microbiology. In this colosseum, young researchers from different fields of specialization who gather under the keyword of “microorganisms” frankly exchange their questions and opinions. In addition to the growth of the participants as researchers, it is expected to build a new network and expand the base of bacteriology in Japan. The 17th Wakate Colosseum for Bacteriology was held in Kurume City Plaza on August 17-19, 2023, under the auspices of the Japanese Society for Bacteriology, and featured heated discussions on cutting-edge topics in the fields of infection, ecology, genomics, and single-cell observation. In this workshop, as a feedback to the members of the Japanese Society for Bacteriology, the contents of the 17th meeting will be reported first, and then the sponsor and the young researchers who made outstanding presentations at the 17th meeting will introduce their own research.
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Convener : Masato Suzuki(National Institute of Infectious Diseases) , Masaki Shintani (Shizuoka University)
Supported by : Ohsumi Frontier Science Foundation
Speakers : Kouhei Kishida (Tohoku University) , Yusuke Hashimoto (Gunma University) , Hirokazu Yano (National Institute of Infectious Diseases) , Hiroshi Nishimasu (The University of Tokyo) , Kotaro Kiga (National Institute of Infectious Diseases)
Overview : Horizontal gene transfer (HGT) is a driving force in the evolution of life. Bacteria acquire genes related to survival and proliferation, such as antimicrobial resistance and degradation genes, through HGT, enabling them to adapt to new hosts and environments. DNA is transferred among bacteria via several mechanisms, such as plasmid conjugation. Plasmids, which replicate outside the chromosome in either circular or linear forms, are mainly transferred via type IV secretion systems. However, HGT is also influenced by defense systems against foreign DNA, including restriction enzymes and CRISPR-Cas systems. These DNA editing enzymes, once discovered, have been harnessed for genetic engineering, making significant contributions to life science research. Recently, numerous defense systems preserved across a broad range of organisms from prokaryotes to mammals have been elucidated. This symposium seeks to explore the latest insights into both the systems that facilitate DNA transfer in bacteria and those that defend against it, aiming to deepen our understanding of the HGT phenomenon.
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Convener : Jumpei Uchiyama (Okayama University) , Masahiro Kusumoto (National Agriculture and Food Research Organization)
Co-sponsorship : Microbiology Subcommittee, Japanese Society of Veterinary Science,Supported by:Nominal sponsorship: Japan Society of One Health Sciences
Speakers : Murzabaev Marse (Anicom Pafe, Inc.) , Keitaro Ohmori (Tokyo University of Agriculture and Technology) , Kiyonori Kawasaki (Kagawa University) , Ryo Inoue (Setsunan University) , Takuya Yagisawa (Hokkaido Agriculture Mutual Aid Association)
Overview : The concept of “One Health” is essential to realize our sustainable society. Particularly, the ‘animal microflora’ is not only relevant to animal health but also to human life and environmental conservation. It is expected, thus, that understanding the animal microflora will help to achieve one of the pillars of One Health: the establishment of a better relationship between the environment, humans, and animals. The animal microflora has the characteristic that high-quality data can be obtained comparatively easily due to the similarity of feeding and behavioral patterns in wild animals and the uniformity of the rearing environment in companion and domestic animals. This feature raises the prospect of its application in companion animals, livestock, and the environment. Examples include gut microflora tests for companion animals and databases of gut microflora for domestic animals. In this session, we would like to invite researchers who are conducting advanced research on animal microflora, share their latest research results, and discuss how animal microflora will be studied and applied in the future.
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Convener : Michinaga Ogawa (National Institute of Infectious Diseases) , Takashi Nozawa (Kyoto University)
Speakers : Sayaka Shizukuishi (National Institute of Infectious Diseases) , Mayuko Oka (Kyoto Prefectural University) , Takeshi Haneda (Kitasato University) , Takashi Nishida (Research Institute for Microbial Diseases , Osaka University) , Hirotaka Hiyoshi (Nagasaki University) , Takashi Nozawa (Kyoto University)
Overview : In host defense, pathogen-specific components such as bacterial proteins, nucleic acids, sugars, and lipids have traditionally been considered non-self; however, the latest research has proposed a new concept in which molecules and events associated with the pathogen’s life cycle within the host are recognized as non-self. Interestingly, it is increasingly evident that pathogens also employ strategies to secure a niche for survival and replication by manipulating the host’s higher biological functions, such as endocytosis, cytoskeleton rearrangement, membrane transport, cell death, and inflammatory responses, through the exploitation of virulence factors that target previously unknown host factors and defense systems. In this workshop, host-pathogen interactions, particularly “self- and non-self-recognition,” will be the focus, and cutting-edge topics will be discussed together with researchers specializing in this field using various bacterial species.
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Convener : Yoshitoshi Ogura(Kurume University School of Medicine) , Taku Oshima (Toyama Prefectural University)
Supported by : Society of Genome Microbiology, Japan
Speakers : Taku Oshima (Toyama Prefectural University) , Yuta Michimori (Kyoto University) , Hiroshi Mori (National institute of genomics) , Ying Beiwen (University of Tsukuba) , Chiho Minakuchi (The University of Tokyo)
Overview : As genome analysis has become easier to perform, basic and applied research using genome sequence information is actively progressing in various fields of microbiology. At the annual meeting of the Japanese Society for Genomic Microbiology, 300 to 500 researchers whose research materials include a variety of microorganisms, from pathogenic microorganisms to environmental microorganisms, participate and lively discussions take place. At this symposium, five researchers representing the Japanese Society for Genomic Microbiology will give presentations on cutting-edge genomic research.
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Convener : Hideki Hara (Asahikawa Medical University) , Yumi Matsuoka (Osaka University)
Speakers : Yasuyuki Matsuda (Asahikawa Medical University) , Yoshinari Nakatsuka (Kyoto University) , Takehiko Shibata (Tokyo Medical University) , Kei Sakamoto (Yamaguchi University) , Yumi Matsuoka (Osaka University)
Overview : Infection with pathogenic bacteria may develop diseases and, in severe cases, lead to death. As a strategy for infection control, preventing the infection is the first priority, and it is also crucial to prevent the progression to severe illness after infection. Traditionally, it has been believed that infections with low-pathogenic bacteria result in recovery, while infections with high-pathogenic bacteria lead to severe illness. However, recent observations from COVID-19 patients have revealed that individuals infected with the same pathogen can experience divergent outcomes, with some developing severe symptoms and others not. It means that the severity of the infectious disease involves not only factors from the pathogens but also various factors from the host and the environment. In this session, we discuss various factors related to the severity of infectious diseases, as revealed by the latest research, focusing not only on bacterial factors but also on host and environmental factors. The aim is to explore a more realistic understanding of the mechanisms underlying severe infections.
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Convener : Yasufumi Hikichi (Kochi University) , Teppei Morita (Keio University)
Speakers : Masanao Sato (Hokkaido University) , Akira Mine (Kyoto University) , Masayuki Tsuzuki (Kochi University) , Ryohei Thomas Nakano (Hokkaido University) , Teppei Morita (Keio University) , Takashi Nozawa (Kyoto University)
Overview : The discovery of the transposon as the mobile element by Dr. Barbara McClintock led to the development of reverse genetics as a novel research strategy. The genome editing developed by Drs. Jennifer Anne Doudna and Emmanuelle Marie Charpentier allowed us to elucidate functions of uncharacterized genes-encoded proteins on phenotypes. Furthermore, the development of multivariate analysis of omics brought us skills and tools to elucidate mysterious life. However, several environmental factors have effects on life and several subsystems are involved in each phenotype so that we have few examples that comprehensively elucidate underlying mechanisms of a phenotype. In this symposium, six of young scientists we are proud to have in Japan will talk about bacteria-host interactions with their excellent studies to address the question “How does systems biology based on the multivariate analysis of omics contribute to bacteriology?”.
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Convener : Yuki Kinjo(Jikei Univ. Sch. Med.) , Ichiro Nakagawa (Kyoto University)
Co-sponsorship : Federation of Microbiological Societies of Japan, Supported by:Japanese Society of Host Defense Research
Speakers : Hiromitsu Hara (Kagoshima Univerisity) , Hiroyasu Tsutsuki (Kumamoto University) , Yuki Kinjo (Jikei Univ. Sch. Med.) , Takeshi Ichinohe (IMS, Univ. of Tokyo) , Makoto Takeda (Univ. of Tokyo)
Overview : The importance of host defense research is rediscovered since the emergence of COVID19 pandemic. In the development of new methods of diagnosis, treatment and prevention of infectious diseases, it is necessary to explore new ways from various views including the elucidation of infection mechanism, pathobiology, and host defense against microbial infections. In this symposium, we uphold the theme of Frontline researches of infectious diseases from the perspective of host defense, and researchers of various fields will present their findings of frontline researches with new aspects in the fields of not only bacteria and fungi but viruses including infection mechanism by pathogens, mechansism and action of virulence factors, mechanism of host defense against infections and immune responses induced by vaccines.
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Convener : Tetsuya Iida (Osaka University) , Sohkichi Matsumoto (Niigata University)
Co-sponsorship : U.S.-Japan Medical Cooperative Medical Sciences Program (USJCMSP)
Speakers : Tetsuya Iida (Osaka University) , Shigeaki Matsuda (Osaka University) , Ken Ishii (Tokyo Univ) , Shinjiro Hamano (Nagasaki Univ) , Akihito Nishiyama (Niigata Univ) , Miki Nagao (Kyoto University)
Overview : The U.S.-Japan Cooperative Medical Sciences Program (USJCMSP) was established in 1965, following a joint communique by then-Prime Minister Eisaku Sato and then-U.S. President Lyndon Johnson, with the objective of combating the spread of diseases in Asia through collaborative efforts between the United States and Japan. In its initial stages, the program addressed Cholera, Tuberculosis, Leprosy, Viral diseases, and Parasitic diseases, with panels organized for each disease. The number of panels has changed in response to the demands of the times, and currently there are 10 panels, including “AIDS,” “Hepatitis,” Viral diseases”, “Acute Respiratory Infections”, Cholera and other Bacterial Enteric diseases,” “Mycobacterial diseases”, “Immunology,” “Cancer,” and “Nutrition and Metabolism. Many leading researchers from both countries have participated and produced achievements so far. In this symposium, we will introduce the USJCMSP and invite researchers from five panels closely related to bacteriology, such as, “Cholera,” ” Mycobacterial diseases,” “Immunology,” “Parasitic diseases,” and “Acute Respiratory Infections”. We would like to provide an opportunity to think about the research that will lead to breakthroughs in the fight against infectious diseases including bacterial infections.
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Convener : Yukihiro Akeda (National Institute of Infectious Diseases)
Speakers : Norihiko Takemoto (The National Center for Global Health and Medicine) , Emiko Rinbara (National Institute of Infectious Diseases) , Yukihiro Akeda (National Institute of Infectious Diseases) , HitoshiTsugawa (Tokai University) , Kosuke Fujimoto (Osaka Metropolitan University)
Overview : The global epidemic of SARS-CoV2 and the spread of drug-resistant bacteria have drastically changed the perception of infectious diseases, and countermeasures against them have been underway globally. On the other hand, research using pathogens as model organisms has encountered huge difficulty in capturing the essence of infectious diseases experienced in actual clinical settings, such as the diversity of microorganisms and pathophysiology in humans. Therefore, the importance of research on infectious diseases (Bench to Bedside/Bedside to Bench) that links basic research and clinical practice has been reaffirmed greatly. In this symposium, Speakers will present a wide range of topics including the importance of infectious diseases in clinical practice, laboratory approaches, and how to connect clinical practice and the laboratory, and we hope that this will help future research in bacteriology and bacterial infections.
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Convener : Hitomi Mimuro (Oita University) , Kimihiro Abe (Natinal Institute of Infectious Diseases)
Co-sponsorship : Research Center for GLOBAL and LOCAL Infectious Diseases, Oita University
Speakers : Kimihiro Abe (Natinal Institute of Infectious Diseases) , Jun Kawamoto (Kyoto University) , Takehiro Yamaguchi (Natinal Institute of Infectious Diseases) , Nobuhide Kobayashi (Kanazawa University) , Mayuko Oka (Kyoto Prefectural University ) , Hitoshi Tsugawa (Tokay University) , Atsunari Kawashima (Osaka University) , Atsunori Tsuchiya (Niigata University)
Overview : Extracellular vesicles (EVs), such as bacterial outer membrane vesicles and eukaryotic exosomes, are spherical structures enveloped in lipid bilayers. They are released as nanoscale particles containing cellular components. Recent studies highlight the pivotal role of EVs in facilitating intercellular communication and horizontal gene transfer through biomaterial transport within cell populations, spanning different biological kingdoms. Capitalizing on the robust stability of cargoes encapsulated within EVs and their potential to elicit host immune responses, EVs are expected as a new modality for drug delivery and vaccine development in medical contexts. Conversely, emerging evidence indicates that EVs can trigger the onset and exacerbation of various infectious and non-infectious diseases by modulating cellular functions. To deepen our understanding of EVs and consolidate our knowledge, this session will feature presentations on the latest advancements in EV research by researchers from various multidisciplinary fields related to bacteriology.
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Convener : Yuki Kinjo (The Jikei University School of Medicine) , Hiroji Chibana (Chiba University)
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Convener : Tomoko Sumitomo (Tokushima University) , Daisuke Nakane (The University of Electro-Communications)
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Convener : Shinji Yamasaki (Osaka Metropolitan University) , Hiromi Nakamura (Osaka Institute of Public Health)
Speakers : Yuki Wakabayashi (Osaka Institute of Public Health) , Emiko Kitagawa (Ishikawa Prefectural Institute of Public Health and Environmental Science) , Noriko Nakanishi (Kobe Institute of Health) , Tadasuke Ooka(Kagoshima University) , Shinji Yamasaki (Osaka Metropolitan University)
Overview : As the COVID-19 has been moved to category 5 infectious disease, people are once again becoming more active and as a result various food poisoning and infectious diseases are beginning to spread. On the other hand, the COVID-19 epidemic also triggered the active use of genomic analysis methods in the epidemiological analysis of food poisoning and infectious diseases. In this workshop, we will present recent cases of food poisoning caused by enteropathogenic Escherichia coli O45, Campylobacter food poisoning caused by food and drink made with spring water, legionnaires’ disease caused by a bath facility, bacteremia caused by the same clone-derived Salmonella Oranienburg strain, and a prolong excretion of Escherichia albertii in a stool specimen of a diarrheal child, which was detected by real-time PCR. In some of these cases, genome analysis of the strains led to the estimation or identification of the source of infection. Thus, we hope that these case studies will help the audience deepen their understanding of the epidemiology of food poisoning and infectious diseases, identify problems, and develop collaborative research that will lead to solutions to these issues.
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Convener : Mikio Tanabe (KEK/High Energy Accelerator Research Organization) , Kunihiko Nishino (Osaka University)
Speakers : Mitsuko Hayashi-Nishino (Osaka University) , Teppei Morita (Keio University) , Chikara Kaito (Okayama University) , Takuya Shiota (Miyazaki University) , Mariko Naito (Nagasaki University) , Yukako Fujinaga (Kanazawa University)
Overview : The bacterial membrane plays a crucial role in a diverse range of functions including selective substance permeation, energy production, sensing and responding to extracellular signals, secretion, and cell wall formation. Membrane proteins mediate these processes, enabling bacterial survival. Advances in technologies, such as genome editing, sequencing, cryo-electron microscopy, and AI, have shed light on macro-level biological phenomena, underscoring the increasing importance of understanding the impact of membrane proteins across the spectrum of life. Molecular-level studies of membrane proteins have lagged behind those of soluble proteins due to their handling difficulties. This symposium will spotlight representative proteins facilitating various membrane reactions. The aim is to reconsider how changes in their expression and function may impact processes such as drug resistance, acquisition of pathogenic factors, cell adhesion, and toxin permeation.
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Convener : Tomomi Kuwahara (Kagawa University) , Hitomi Mimuro (Oita University)
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Convener : Nozomu Obana (University of Tsukuba) , Hiraku Takada , (Kyoto Sangyo University)
Co-sponsorship : JST-ACT-X
Speakers : Nozomu Obana (University of Tsukuba) , Hiraku Takada (Kyoto Sangyo University) , Yosuke Nishimura (JAMSTEC) , Yohei Nishikawa (AIST) , Yoshihide Tokunou (University of Tsukuba)
Overview : The emergence and spread of drug-resistant bacteria is one of the significant social problems. Under these circumstances, there is an urgent need to understand the detailed mechanisms of antibiotic action, how bacteria survive against antibiotics and diverse environments, and their survival strategies. In addition, investigating antibiotic resistance mechanisms, the diversity of regulatory mechanisms, and their evolution in environmental bacteria is an approach to unraveling interaction that microorganisms have been engaged in continuously since about 3 billion years ago. This is an important topic not only in clinical but also in basic bacteriological research.
In this workshop, young researchers will report on their current efforts to explore and elucidate various antibiotic resistance mechanisms and environmental survival strategies using innovative technologies such as metagenomics, Cryo-EM, single-cell analysis, microbial electrochemistry, and genetic and molecular biological methods. This session aims to discuss the future prospects of these studies.
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Convener : Manabu Ato (National Institute of Infectious Diseases) , Kinnosuke Yahiro (Kyoto Pharmaceutical University)
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Convener : Takashi Shimizu (Yamaguchi University) , Chikara Kaito (Okayama University)
Co-sponsorship : NBRP Paramecium
Speakers : Torahiko Okubo (Hokkaido University) , Kazuya Ishikawa (Okayama University) , Yugo Kitazawa (The University of Tokyo) , Takashi Shimizu (Yamaguchi University) , Hiroshi Hamamoto (Yamagata University) , Ryota Nomura (Hiroshima University)
Overview : In bacteriology, infection experiments are essential for understanding the interaction between bacteria and host organisms. Up to now, mammalian animals such as mice and rats have been mainly used in infection experiments. However, in such animal experiments, it is essential to minimize the number of animals used from an animal welfare point of view, and it is difficult to perform many experiments by trial and error. In addition, to understand the dynamics of bacteria in their natural environment, infection models that closely resemble their natural hosts in nature are needed. However, it has been difficult to prepare such model organisms.
In recent years, several infection models have been proposed to alleviate such ethical and resource problems. In addition, the National BioResource Project conducted by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) has collected various organisms that form the basis of life science research, and these organisms can be easily used.
Against this background, researchers working on infectious diseases using various infection models such as ciliates, silkworms, and plants will present the frontiers of their research in this workshop.
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Convener : Keigo Shibayama (Nagoya University) , Hitoshi Komatsuzawa (Hiroshima University)
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Convener : Shinichi Yokota (Sapporo Medical University)
Speakers : Yoshihiro Fujiya (Sapporo Medical University) , Koji Kuronuma (Sapporo Medical University) , Satoshi Takahashi (Sapporo Medical University)
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Early detection and improvement of the increasing asymptomatic patients —For the purpose of early detection and improvement of the increasing asymptomatic patients screened by stool test inspection that is defined in “Manual for Hygiene Management at Large-scale Food Preparation Facilities”
Sponsored by Japan Biosciences Co., Ltd.
Speakers : Toshio Sato (Manager of Quality Control Department, JAPAN BIOSCIENCES CO., LTD.)