Basic Lecture

June 10 (Mon)13:00-14:40
[Session Language: Japanese]

PSSJ Basic course: Structural basis for protein spectroscopy and the fundamentals of protein spectroscopy

Organizers: Masafumi Yohda (Tokyo Univ. of Agri. and Tech.), Susumu Uchiyama(Osaka Univ.)

Akinori Kidera (Yokohama City Univ.)
Yukihiro Ozaki (Kwansei Gakuin Univ.)

The importance and necessity of spectroscopy in drug discovery and production of protein drugs has been recognized, and spectroscopic techniques such as infrared, Raman, and circular dichroism have been continuously developed. In this PSSJ basic course, we will have lectures from leading scientists on the structural basis for understanding protein spectroscopy and the fundamentals of protein spectroscopy. The workshop of the Protein Engineering will be held after the basic lecture on the theme of the use of spectroscopy.


June 11 (Tue) 9:15-11:45
[Session Language: English]

The trend in protein science aiming to address pandemic challenges.

Organizer: Katsumi Maenaka(Hokkaido Univ.)

Erica Saphire(La Jolla Institute for Immunology)
Yoshimasa Takahashi(National Institute of Infectious Diseases, Research Center)
Yuqi(Gary) Zhang(Schrodinger)
Hideo Fukuhara(Hokkaido Univ.)
Shota Uehara (Shionogi & Co., Ltd.)

The emergence of the COVID-19 pandemic, instigated by SARS-CoV-2, has imposed profound global ramifications. In response, an intensive scientific pursuit has ensued, focusing on the development of vaccines and neutralizing antibodies. Central to these efforts lies the foundation laid by research in SARS-CoV-2 protein science. This symposium endeavors to convene eminent scholars engaged in cutting-edge investigations, encompassing structural and immunological analyses of neutralizing antibodies, therapeutic development targeting the main protease, and in silico methodologies. Through their discourse, we aspire to elucidate the trajectory of protein research in anticipation of future pandemics.

Young Scientist Award Symposium

June 12(Wed) 9:15-11:30
[Session Language: English]
Chairs: Eriko Nango (Tohoku Univ.), Mitsunori Ikeguchi(Yokohama City Univ.)


Day 1 June 11 (Tue)

WS1 16:00-18:30
[Session Language:Japanese]

Protein Science from Multifaceted Perspectives

Organizers: Hideki Taguchi (Tokyo Inst. of Tech.), Yoshikazu Tanaka (Tohoku Univ.)

Hideki Taguchi(Tokyo Inst. of Tech.)
Masaki Matsumoto(Niigata Univ.)
Ryotaro Koike(Nagoya Univ.)
Munehito Arai(The Univ. of Tokyo)
Suzuka Ono(Kyoto Sangyo Univ.)
Tomohiro Yamazaki(Osaka Univ.)
Yoshikazu Tanaka(Tohoku Univ.)

Recent progresses are revolutionizing the traditional view of proteins as “the ribosome translates mRNA from start codon to stop codon, and the completed polypeptide chain folds and functions”. This workshop will introduce the state-of-the-art of multifaceted protein science by those pursuing protein science from a viewpoint beyond the canonical view.
WS2 16:00-18:30
[Session Language:Japanese]

Cell-free protein synthesis based molecular systems for new protein science

Organizers: Ken-ichi Nishiyama (Iwate University) Tomoaki Matsuura (Tokyo Institute of Technology)

Ken-ichi Nishiyama (Iwate University)
Tomoaki Matsuura (Tokyo Institute of Technology)
Shoko Fujita (Tokyo University of Agriculture and Technology)
Gosuke Hayashi (Nagoya University)
Teruyo Kato (Nagoya University)
Yuzuru Tozawa (Saitama University)

Cell-free protein synthesis (CFPS) is a system that can synthesize proteins in vitro. In this session, we will present the latest research results using CFPS. Lectures will be given on a wide range of topics including screening, directed evolution, functional analysis of proteins, and elucidation of protein translation mechanisms.
WS3 16:00-18:30
[Session Language:Japanese]

The Present and Future of Peptide Design

Organizers: Masahito Ohue (Tokyo Institute of Technology) Masatake Sugita (Tokyo Institute of Technology)

Masatake Sugita (Tokyo Institute of Technology)
Ai Niitsu (RIKEN)
Yuki Murakami (Yokohama City University)
Shunji Suetaka (The University of Tokyo)
Naoya Kobayashi (NAIST)
Masahito Ohue (Tokyo Institute of Technology)

The workshop gathers new researchers to exchange insights on peptide research’s advances and its applications in drug discovery, assessing both the contributions of AI technologies like AlphaFold and identifying areas that require further exploration. The goal is to advance understanding and innovation in the field.
WS4 16:00-18:30
[Session Language:English]

Exploring the true nature of proteins - Challenges of linking protein structure, physical properties, and functions -

Organizers: Chojiro Kojima (Yokohama National University) Koh Takeuchi (The University of Tokyo)

Mitsunori Ikeguchi (Yokohama City University)
Takayuki Kato (Osaka University)
Mako Kamiya (Tokyo Institute of Technology)
Daisuke Koda (Kyushu University)
Koh Takeuchi (The University of Tokyo)
Kouhei Tsumoto (The University of Tokyo)

Recent advancements in protein structural study give over 200,000 structures in the Protein Data Bank and predict three-dimensional structures from amino acid sequences accurately. Despite these progresses, understanding proteins’ dynamic aspects and functional properties remains challenging. The workshop focuses on sharing innovative post-structural studies to address these limitations and unveil the true nature of proteins.
WS5 16:00-18:30
[Session Language:Japanese]

Various structural designs of artificial antibodies

Organizers: Takeshi Nakanishi (Osaka Metropolitan University) Koki Makabe (Yamagata University)

Koki Makabe (Yamagata University)
Masahiro Kawahara (National Institutes of Biomedical Innovation, Health and Nutrition)
Ryutaro Asano (Tokyo University of Agriculture and Technology)
Kyohei Sato (Tohoku University)
Makoto Nakayama (Kyowa Kirin Co., Ltd.)
Junichi Takagi (Osaka University)
Takeshi Nakanishi  (Osaka Metropolitan University)

Antibody engineering, one of the protein engineering techniques, has become a fundamental technology for antibody-based drug development. This field has further advanced in various ways, including creating antibody drugs with new functions and developing biosensors through various structural re-designs that greatly modify the natural antibody structures. In this workshop, we will focus on the various “shapes” of artificially designed antibodies and will overview the achievements and prospects of this field through talks by cutting-edge researchers.

Day 2 June 12 (Wed)

WS6 16:00-18:30
[Session Language:Japanese]

Frontline of cross-scale biology

Organizers: Masahide Kikkawa (The University of Tokyo) Noritaka Nishida (Chiba University)

Sasaki Ryohei (The University of Tokyo)
Kazuki Watanabe (Chiba University)
Shohei Fujii (Tohoku University)
Shingo Tamai (RIKEN CBS)
Tsuyoshi Imazaki (Kobe University)
Kyoko Chiba (Tohoku University)
Takahiro Nagao (The University of Tokyo)
Goro Nishide (Kanazawa University)

In our research area, we aim to elucidate various biological phenomena occurring within cells by developing and applying various cross-scale measurement techniques to visualize the atomic and molecular-level structures of proteins to the spatiotemporal dynamics at the level of organelles and cells. In this workshop, eight young researchers, actively engaging at the frontline of cross-scale measurement research, will present their latest findings.
WS7 16:00-18:30
[Session Language: English]

Workshop in Collaboration with PS and APPA

Organizers: Atsushi Nakagawa(Osaka Univ.) Katsumi Maenaka(Hokkaido Univ.)

Elizabeth Meiering(Univ. of Waterloo)
Yun-Ru (Ruby) Chen(Academia Sinica)
Kwang Yeon Hwang(Korea Univ.)
Sun Choi(Ewha Womans Univ.)
Yonggui Gao(Nanyang Technological Univ.)

This symposium is organized by the headquarters of Protein Science Society of Japan to facilitate collaboration with Protein Socoiety and Asian Pasific Association. The President of PS, the chair and member of APPA, the present and former presidents of Protein Socoiety in Korea are invited.

WS8 16:00-18:30
[Session Language:English]

Exploring Protein Self-Condensation Mechanisms in Dynamic Solution Environments: New Perspectives and Future Vision

Organizers: Naotaka Sekiyama (Kyoto University) Kenji Sugase (Kyoto University)

Naotaka Sekiyama (Kyoto University)
Kenji Sugase (Kyoto University)
Hideki Nakamura (Kyoto University)
Norio Yoshida (Nagoya University)
Ayako Furukawa (Kyoto University)
John E. Straub (Boston University)

Intrinsically disordered proteins (IDPs) regulate various cellular functions via self-condensation, such as liquid-liquid phase separation and amyloid fibrillization in response to the physical and chemical solution environments. In this workshop, we will discuss the latest research in the IDP self-condensation regulated by dynamic solution environments.
WS9 16:00-18:30
[Session Language:English]

Current trends in analytical technologies for development and quality control of next-generation therapeutic antibodies that maximize the value of proteins

Organizers: Akiko Ishii-Watabe (National Institute of Health Sciences) Kouhei Tsumoto (The University of Tokyo)

Akiko Ishii-Watabe (National Institute of Health Sciences)
Noritaka Hashii (National Institute of Health Sciences)
Satoru Nagatoishi (The University of Tokyo)
Koichi Kato (National Institutes of Natural Sciences)
Masato Kiyoshi (National Institute of Health Sciences)
Susumu Uchiyama (Osaka University)
Kouhei Tsumoto (The University of Tokyo)

Development of engineered next-generation therapeutic antibodies has expanded. This workshop focuses on the progress of AMED project on “Research on quality evaluation that promotes the development of next-generation therapeutic antibodies”. The latest topics in analytical technologies are introduced, and contribution of protein science in future drug development will be discussed.
WS10 16:00-18:30
[Session Language:Japanese]

Multi-omics data analyses for promoting protein science

Organizers: Kengo Kinoshita (Tohoku University) Kei Yura (Ochnomizu University)

Yoichiro Kamatani (The University of Tokyo)
Matsuyuki Shirota (Tohoku University)
Susumu Yamanobe (Japan Agency for Medical Research and Development)
Yutaka Suzuki (The University of Tokyo)
Seizo Koshiba (Tohoku University)
Hiroko Matsunaga (Waseda University)

In the field of protein research, the availability of omics data is rapidly expanding. However, due to differences in culture and data handling across various disciplines, its full potential has not yet been fully realized. This session aims to promote cross-disciplinary fusion and collaboration to effectively utilize a wealth of resources, including genomic data, and pave the way for multi-omics analysis to accelerate protein research.

Day 3 June 13 (Thu)

WS11 8:30-11:00
[Session Language: English]

PSSJ-Devision for bio-analysis of SBJ-JPrOS joint workshop

Organizers: Susumu Uchiyama (Osaka Univ.), Takeshi Bamba(Kyushu Univ.), Yasushi Ishihama(Kyoto Univ.)

Takeshi Masuda (Keio Univ.)
Yasushi Ishihama (Kyoto Univ.)
Fumio Matsuda (Osaka Univ.)
Wataru Aoki (Osaka Univ.)
Kengo Kinoshita (Tohoku Univ.)

Multiomics research has been actively conducted. In this workshop, researchers from three related societies will present the recent situation and the latest research results on proteomics, metabolomics, and the analysis of structures and functions of multiple types of proteins, focusing on proteins that play a central role in biological functions. We hope that this meeting will provide an opportunity to further expand the scope of protein science.

WS12 8:30-11:00
[Session Language:Japanese]

Unveiling the kinetic-driven LLPS mechanism by the cutting-edge technologies

Organizers: Tomohide Saio (Tokushima University) Masaki Okumura (Tohoku University)

Takahiro Muraoka (Tokyo Univ. of Agri. and Tech.)
Shunsuke Shimobayashi (Kyoto University)
Eiichiro Mori (Nara Medical University)
Masaki Okumura (Tohoku University)
Maho Yagi-Utsumi (Nagoya City University)
Takakazu Nakabayashi (Tohoku University )
Lee Young-Ho (Korea Basic Science Institute)
Hiroyuki Uechi (Tohoku University)

Despite the accumulating knowledge of LLPS controls in the biological events such as stress granule, structural information within the droplet remains obscure. This workshop will feature the latest studies from scientists who use the cutting-edge technologies from the aspects of molecules, proteins, organelles, and cellular dynamics.
WS13 8:30-11:00
[Session Language:Japanese]

Frontier of interdisciplinary protein engineering

Organizers: Naohiro Terasaka (Tokyo Institute of Technology) Yuta Suzuki (JST PRESTO)

Koji Oohora (Osaka University)
Takahiro Mori (The University of Tokyo)
Yusuke Nasu (The University of Tokyo)
Ai Kohata (Tokyo Institute of Technology)
Shingo Honda (University of Washington)
Naohiro Terasaka (Tokyo Institute of Technology)

Recent protein engineering research has been collaborated with various research fields such as chemical biology, inorganic chemistry, structural biology, and computer science to create functional molecules that potentially surpass natural ones. In this workshop, we will introduce the cutting-edge interdisciplinary research and discuss the future direction in protein engineering.
WS14 8:30-11:00
[Session Language:Japanese]

Where Bioinformatics and Agrochemistry Meet
(Joint Workshop of PSSJ and JSBBA supported by AMED-BINDS)

Organizers: Shinya Fushinobu (The University of Tokyo) Masakazu Sekijima (Tokyo Institute of Technology)

Masakazu Sekijima (Tokyo Institute of Technology)
Atsushi Yamagata (RIKEN BDR)
Keisuke Yanagisawa (Tokyo Institute of Technology)
Kohji Murase (The University of Tokyo )
Tomomi Sumida (JAMSTEC CeBN)

The study of protein structure and dynamics not only contributes to medicine and drug discovery, but also reveals key interactions that enable the survival of plants and microorganisms that form the global environment. In this WS, mainly young Speakers will present their research integrating bioinformatics and structural biology under the support of AMED-BINDS, which conducts protein research support projects in collaboration with the Japanese Society for Bioscience, Biotechnology and Agrochemistry.
WS15 15:40-18:10
[Session Language:Japanese]

Crossover between Protein Science and AI

Organizers: Hafumi Nishi (Tohoku University) Kentaro Tomii (AIST)
Hafumi Nishi (Tohoku University)
Kentaro Tomii (AIST)
George Chikenji (Nagoya University)
Yoshitaka Moriwaki (The University of Tokyo)
Daisuke Kihara (Purdue University)
Ryuichiro Ishitani (Tokyo Medical and Dental University)
With the advent of advanced AIs like AlphaFold2 and RFDiffusion, structural biology and protein science are undergoing significant changes. This workshop introduces researchers’ efforts in adapting to these trends and discusses the effectiveness, limitations, and potential future challenges of AI in the field of protein science.
WS16 15:40-18:10
[Session Language:English]

Molecular design for expanding protein functions -Challenges and Prospects-

Organizers: Shigehiko Hayashi (Kyoto University) Eriko Nango (Tohoku University)

Robert E. Campbell  (The University of Tokyo)
Florence Tama (Nagoya University)
Tomohiro Nishizawa (Yokohama City University)
Keiichi Inoue (The University of Tokyo)
Nobuyasu Koga (Osaka University)

Now that the prediction of protein structure from amino acid sequence has been revolutionized by AlphaFold2 and other cutting edge computational approaches, the next frontier of protein science is to enable flexible conversion and creation of protein functions based on dynamic structures of proteins. For this workshop, we invite scientists with expertise in areas including the theoretical prediction of protein structural changes, dynamic structural analysis of proteins, and directed evolution and de novo design of proteins. In addition, we invite researchers in application fields that are being opened up by the development of new functional proteins to attend this symposium and discuss methods and prospects for the future of functional protein design.

WS17 15:40-18:10
[Session Language:English]

Frontiers of in-cell protein trafficking, structures and functions

Organizers: Takuya Shiota (University of Miyazaki) Yuhei Araiso (Kanazawa University)

Li Long (Peking University)
Masato Nakai (Osaka University)
Yoichi Miyamoto (NIBIOHN)
Ryoji Miyazaki (NAIST)
Edward Germany (University of Miyazaki)
Nanako Kobasyashi (Kanazawa University)

Protein trafficking is essential process in cell. Since Blobel’s “signal hypothesis,” various factors have been identified. Recently, technological advances in structural analysis reveals molecular mechanisms in detail surprisingly and functional analysis reveals mechanisms that exceeded predictions. In this session, we would like to discuss new concepts of protein trafficking.
WS18 15:40-18:10
[Session Language:Japanese]

Recent advances in protein science using NMR spectroscopy

Organizers: Tomoyasu Aizawa (Hokkaido University) Izuru Kawamura (Yokohama National University)

Masaki Mishima (Tokyo University of Pharmacy and Life Sciences)
Kaoru Nomura (Suntory Foundation for Life Sciences)
Tomohide Saio (Tokushima University)
Eri Chatani (Kobe University)
Tomoyasu Aizawa (Hokkaido University)
Izuru Kawamura (Yokohama National University)

Nuclear Magnetic Resonance (NMR) spectroscopy enables the investigation of dynamic structure of proteins at atomic resolution. Ongoing advancements in NMR techniques facilitate the examination of proteins in crowding biosystems, membrane proteins, and amyloid fibrils. This workshop aims to present recent protein research utilizing biological solution and solid NMR technology.
WS19 15:40-18:10
[Session Language:Japanese]

Frontiers of translational control studies in model organism Escherichia coli

Organizers: Takehito Tanzawa (Osaka University) Tatsuya Niwa (Tokyo Institute of Technology)

Takashi Kanamori (GeneFrontier Corp.)
Tsukumi Miwa (Tokyo Institute of Technology)
Atsushi Minami (The University of Tokyo)
Hideji Yoshida (Osaka Med. Pharm. University)

Translation is constituted of multi-step quality controls, which are complicated but sophisticated. Recent analytical advances and experimental expansion including cell-free translation system make the dynamics of translational control factors acting in cis/trans on ribosome reveal. This workshop will focus on the frontiers of translational control studies in Escherichia coli, which has long been used as a protein expression system.

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The 24th Annual Meeting of the Protein Science Society of Japan All Rights Reserved.